DOP1_MOUSE
ID DOP1_MOUSE Reviewed; 2399 AA.
AC Q8BL99; Q80XM5; Q8BIX5; Q8BIY4; Q8BLK8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein dopey-1 {ECO:0000305};
GN Name=Dop1a; Synonyms=D9Ertd809e, Dopey1 {ECO:0000312|MGI:MGI:1289294};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-1252 (ISOFORM 6), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-726 (ISOFORM 5).
RC STRAIN=C57BL/6J;
RC TISSUE=Corpora quadrigemina, Embryo, Lung, Ovary, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1261, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC early endosomes. {ECO:0000250|UniProtKB:Q03921}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q03921}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8BL99-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BL99-2; Sequence=VSP_027424, VSP_027426;
CC Name=3;
CC IsoId=Q8BL99-3; Sequence=VSP_027418, VSP_027427, VSP_027428,
CC VSP_027429;
CC Name=4;
CC IsoId=Q8BL99-4; Sequence=VSP_027420, VSP_027421;
CC Name=5;
CC IsoId=Q8BL99-5; Sequence=VSP_027422;
CC Name=6;
CC IsoId=Q8BL99-6; Sequence=VSP_027419, VSP_027423, VSP_027425;
CC -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK044820; BAC32105.2; -; mRNA.
DR EMBL; AK045873; BAC32517.1; -; mRNA.
DR EMBL; AK052544; BAC35032.1; -; mRNA.
DR EMBL; AK054511; BAC35807.1; -; mRNA.
DR EMBL; AC157998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043710; AAH43710.1; -; mRNA.
DR AlphaFoldDB; Q8BL99; -.
DR STRING; 10090.ENSMUSP00000140740; -.
DR iPTMnet; Q8BL99; -.
DR PhosphoSitePlus; Q8BL99; -.
DR jPOST; Q8BL99; -.
DR MaxQB; Q8BL99; -.
DR PeptideAtlas; Q8BL99; -.
DR PRIDE; Q8BL99; -.
DR ProteomicsDB; 277590; -. [Q8BL99-1]
DR ProteomicsDB; 277591; -. [Q8BL99-2]
DR ProteomicsDB; 277592; -. [Q8BL99-3]
DR ProteomicsDB; 277593; -. [Q8BL99-4]
DR ProteomicsDB; 277594; -. [Q8BL99-5]
DR ProteomicsDB; 277595; -. [Q8BL99-6]
DR UCSC; uc009qxd.2; mouse. [Q8BL99-4]
DR UCSC; uc009qxe.2; mouse. [Q8BL99-2]
DR UCSC; uc009qxl.2; mouse. [Q8BL99-3]
DR MGI; MGI:1289294; Dop1a.
DR eggNOG; KOG3613; Eukaryota.
DR InParanoid; Q8BL99; -.
DR PhylomeDB; Q8BL99; -.
DR ChiTaRS; Dop1a; mouse.
DR PRO; PR:Q8BL99; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BL99; protein.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005798; C:Golgi-associated vesicle; ISO:MGI.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR040314; DOP1.
DR InterPro; IPR007249; Dopey_N.
DR PANTHER; PTHR14042; PTHR14042; 2.
DR Pfam; PF04118; Dopey_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..2399
FT /note="Protein dopey-1"
FT /id="PRO_0000297948"
FT REGION 556..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..1852
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027418"
FT VAR_SEQ 294..302
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027419"
FT VAR_SEQ 331..364
FT /note="AMVGILQVNGFGEESTLMQDLKPFRILISLLDKP -> VTAVFIILCLSYIE
FT KA (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027420"
FT VAR_SEQ 365..2399
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027421"
FT VAR_SEQ 446..453
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027422"
FT VAR_SEQ 492
FT /note="L -> LPTRSMRVLCQ (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027423"
FT VAR_SEQ 571..584
FT /note="QVSSVSMENPAEVF -> VISVGVHFFGVEFH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027424"
FT VAR_SEQ 571
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027425"
FT VAR_SEQ 585..2399
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027426"
FT VAR_SEQ 1853..1862
FT /note="RKFSFRTGAD -> MLQFFYAYIQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027427"
FT VAR_SEQ 2164
FT /note="Q -> QVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITEL (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027428"
FT VAR_SEQ 2282..2298
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027429"
SQ SEQUENCE 2399 AA; 269257 MW; 1567AD9CE4DBA01E CRC64;
MNTEELELLS DSKYRNYVAA IDKALKNFEY SSEWADLISA LGKLNKVLQN NAKYQVVPKK
LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA KDLFLYSSGL FPLLANAAMS
VKPALLGLYE MYYLPLGKTL KPGLQGLLTG ILPGLEEGSE YYERTNTLLE KVAAAVEQSA
FYSALWGSLL TSPAVRLPGI TYVLAHLNRK LSMEDQLYII GSDIELMVEA VSTSVQDSSV
LVQRSTLDLI LFCFPFHMSQ ATRPDMIRIL SAALHVVLRR DMSLNRRLYA WLLGFDNNGA
IIGPRSTRHS NPEEHATYYF TTFSKELLVQ AMVGILQVNG FGEESTLMQD LKPFRILISL
LDKPELGPVI LEDVLIEVFR TLYSQCKAEL DLQMEPPFSK DHAQLSSKLR ENKKTAELIK
TANLLFNSFE PYYMWDYIAR WFEECCRQSF FLSRRTLHAR LQVGPGDSSD SSELQLTNFC
LLVDFLLDIV SLETYIEIQT EHLPQLLLRM ISALTSHLQT LRLSELTDSL RLCSKILSKV
QPPLLSAGNG GVVQFPSGQN STVKEWEDKK QVSSVSMENP AEVFEDGENP PSSRSSESGF
TEFIQYQADR PDDLDRELNG QGAATIPIGS TSSETETAST VGSEETVIQP PSTFTQGAAG
RSGKAVQKTA MQCCLEYVQQ FLSRLINLYI IHSDSFPQAL AADHQGDFSR IQRETSKWDR
DSQGDAKERN IHTPKTSKEY LSAFLAACQL FLECSSFPVY IAEGNHTSES HSEKPDTDCE
HAHPPQWLRT LMSACSQARD FRVQSAAVSL VMDLVGLTQS VAMVTGENIN SMEPAQPLSP
NQGRVAVVIR PPLTQGNLKY IAEKTEFFKH VALTLWDQLG DGTPQHHQKS VELFYQLHNL
VPSSSICEDV VSQQLTHKDK KIRMEAHAKF AVLWHLTRDL HINKSSFARS FDRSLFIMLD
SLTSLDGSTS SVGQAWLNQV LQRHDIARVL EPLLLLLLHP KTQRVSVQRV QAERYWSKTS
CYPGEENDKH FMQNFTCNNV SQVHLIASKG NGEKPLTMDE MENFSLTVNP LSDRLSLLST
SSETIPMVVS DFDLPDQQME ILQSSDSGCS QSSAGDNFSY EVDPENANAH EDSHMAKASS
PDDDVQQVVF DLICKVVSGL EAESESVTSE LEIESLQTKS SDLDPGKEAT KIEDQAPQHS
QHVLLSDDSP RFLSVSTEEG CECLANGISR NSSSPCISGT AQTLNDSSVP SETKSRQRSH
SSIQFSFKEK LSEKVSEKET IVKESGKQPG AKPKVKLARK KDEDKKKAAS EKLKQANVFF
SEGLDLENWY SCGEGEISEI ESDMGSPGSR KSPNFNIHPL YQHVLLYLQL YDSSRTLYAF
SAIKSILKTN PIAFVNAIST TSVNNAYTPQ LSLLQNLLAR HRISVMGKDF YSHIPVDSNH
NFRSSMYIEI LISLCLYYMR SHYPTHVKVT TQDLIGNRNM QMMSIEILTL LFTELAKVIE
SSAKGFPSFI SDMLSKCKVQ KVILHCLLSS IFSVQKWHSE KTAGKSMVAV EEGFSEDSLI
NFSEDELDNG STLQSQLLRV LQRLIVLEHH VMTIPEENEA GFDFVVSDLE HISPHQPMTS
LQYLHAQPIT CQGMFLCAVI RALHQHCACK MHPQWIGLIT STLPYMGKVL QRVVVSVTLQ
LCRNLDNLIQ QYKYETGLSD SRPLWVASII PPDMILTLLE GITAIIHYCL LDPTTQYHQL
LVNVDQKHLV EARSGILSIL HMIMSSVTLL WSILHQADAS EKMAVAASAS VTTINLGATK
VIPAASEEQL LLVELVRSIS VMRAETVIQT VKEVLKQPPA IAKDKVRKLC FCRKFSFRTG
ADRIPVPNIV DSWTSLLVLL KDSIQLSLPA PGQFLILGVL NEFIMKNPSL ENKKDQRDLQ
DVTHKIVDAI GAIAGSSLEQ TTWLRRNLEV KPSPKIMVDG TNLESDVEDM LSPAMETSNI
TPSVYSVHAL TLLSEVLAHL LDMVFYSDEK ERVIPLLVNI MHYVVPYLRN HSAHNAPSYR
ACVQLLSSLS GYQYTRRAWK KEAFDLFMDP SFFQMDASCV SHWRAIMDNL MTHDKTTFRD
LMTRVAVAQS SSLNLFANRD VELEQRAMLL KRLAFAVLSS ESDQYQKYLP DIQERLVESL
RLPQVQVFLL MEQELTADED ISRTSGPSAA GLETTYTGGN GFSTSYNSQR WLNLYLSACK
FLDLALALPS ENLPQFQMYR WAFIPEASDD SGLEVRRQGI HQREFKPYVV RLAKLLRKRA
KDEEDFKILE GLEMAKHQKN PEEDCSGRTL GWEPGHLLLT LCTMRNMEQL LPFFNVLSQV
FNSKVTSRCG GHSGSPVLYP NSFPNKDMKL ENHKAFSSKA RQKIEEMIEK DFLEGVIKT
