ID   DOP2_XENLA              Reviewed;        2270 AA.
AC   Q642P2;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Protein dopey-2 {ECO:0000305};
GN   Name=dop1b; Synonyms=dopey2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC       early endosomes. {ECO:0000250|UniProtKB:Q03921}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q03921}.
CC   -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
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DR   EMBL; BC081251; AAH81251.1; -; mRNA.
DR   RefSeq; NP_001087807.1; NM_001094338.1.
DR   RefSeq; XP_018103856.1; XM_018248367.1.
DR   AlphaFoldDB; Q642P2; -.
DR   GeneID; 447631; -.
DR   KEGG; xla:447631; -.
DR   CTD; 447631; -.
DR   Xenbase; XB-GENE-1217371; dop1b.S.
DR   OMA; NHSAYNT; -.
DR   OrthoDB; 29961at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 447631; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR040314; DOP1.
DR   InterPro; IPR007249; Dopey_N.
DR   PANTHER; PTHR14042; PTHR14042; 1.
DR   Pfam; PF04118; Dopey_N; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..2270
FT                   /note="Protein dopey-2"
FT                   /id="PRO_0000297950"
FT   REGION          548..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1084..1145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1084..1098
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1099..1145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2270 AA;  256847 MW;  451BAFF3A51DD0B8 CRC64;
     MDVEEQELLG DYRYRNYSSV IEKALRNFES SSEWADLISS LGKLNKALQT NLKYCLLPRR
     IIISKRLAQC LHPALPSGVH LKALETYEII FKIIGTKCLA KDLFLYSSGL FPLLSHAAMS
     VRPILLGLYE TYFIPLQRAL LPSLQAFITG LLPGLEEGSE IYERTDQLLQ RLSVVVGQNV
     FYGSLWGSVL VSSSIRLPAS LFVVSHINKD LSAQSQSYML GKDQELAIKS LCASVVDSNV
     LVQRNTLEIL LFFFPFNTCL VPDECSMLLH RSDMVRILAG SIQTVLRRDM SLNRRLFAWL
     LGSDIKGRHM APELKDSSGD EEYCNHFFAR YSKDLLVEAL MQILHQNTLA SDTEQGLLVY
     LKPFRILVSL LDKPEIGPPV VGELFLEVMR AFIAYCRDAL GTQMQLSYSQ NGAQLISAIK
     ENKNASEIVK TVNLLISSLS SDFLWDYMTI CFEDSFRRKD HDTPAGNYLG RAPSITEVCS
     LLVFLLDVIP LELYSEVQTQ YLPQMLSFMA HSLSDNMDVL SLPELTLALK TCFKVLSKVQ
     MPPAFLDMET PSSDTDPLKE SENNPAPEVE GEMADDDPVF HPLKSEDSGI GLSASSPELS
     KHLRMPRVCP DKGDVWKKGG SMQMTLHCFQ ELVANFASKH LFRIQLKGEG QNSPENGVMT
     ENDMNTKKRG SWQPKQITGP QFKQMLTDFF TPRAPMLKQR SEQSPNKTTN KETEEEWDIE
     RLLQNTGEMK EDCREALAAA CHVLLDCATF PVYMSEEETE HLYSVLSQVP GSSDVSFPLW
     FKTLMMVCCC VKDCYIQNVA ISTLLEVINH SQSLSLVLAD RMKRSKTPGF GEVFGKLQMV
     TIPPVSPGVL KLIADKTDFY PRVAHVLWNQ LNIETREHHI TCVELFYRLH CLAPSANICE
     EIICQTLLHN DKLTRLEALF RFSVIWHLTR EIQGSRVTSH NRSFDRSLFV VLDSLNCSDG
     AIGAAAQGWL VRALSLNDVA RILEAVFLLL LHPKTQRNSI HCIKQKNSSE EFSYWCRKKR
     TSLKDLAAFR DSPLSSSEEN LPQFNTVDRD ALWAEVEKDP EKIKNELTEK RPADFRDAPY
     CVEQEQDYSE HTESADTSTG HNDSDNTSSF TPSSVDLSSD QNYRDNTAGQ VTHKNTGQQN
     MDMPRQNTLL TLVRTESDVT QTSESLSSDD EADLELQAIR SSQLLKQQKE KEEMIEALFK
     HILLYLQPYD SKRVLYAFTV LEAILKTNPK EFIESVAATS MDTSSTAHLN LIYNLLARHQ
     EALVGQSFYG KLQTQSPLMC PHSLLIELLT YLCLSFLRSY YPCYLKVSHK DVLGNRDVQV
     KSVEVLIRIM SQLVNIAKSA EGKKVEFIRF LLERCKVQEF VLLSLSASMY TSQKKYELMS
     AGGNRGIDLG FFEEGIINFG QDQIWSEHPL QIELLKLLQV LIVLEHHLRQ LQDDQDTHGD
     LTKEWQRGIN FQQSINAMQY VQAHSITSQG LFVSAVVKAL RPDYGYGMHP QWVALVTSSL
     PFFGKSLGLT VAPFVVQICK NLDELVKQYE NESFKISTTS KRENVSPDYP LTLLEGLTMI
     GHFCLLDHPT QSKKSSSSDP ANLKNARNAL LEELPRIINT MSLLWSIISK QEREKRPSDL
     LGTIKASSSV YFKSTKTLKQ KILDFLNPLT SHLGVQLIAA VAAVWKKKRF NKSLSKAKIL
     PVPSESQLIF VDLVCALKTL KTDTILHLVK EVVKKPPQIK GDEKSSLVDI PMLQFSYTFI
     QRLSGSELQE NSQSLLALLK ESVPLNLAPP GFFLLLSMLN DFVTRTPNLE SKKDQKELQE
     VTQKILEAVG NVAGSSLEQT SWLSRNLEVK AQPQISLDDA EAEEEDLNDD SVVAQSSMVS
     ASAPSMYSVQ ALSLLAEVLA NLLDMVYRSD EKEKAVPLIS RLLYYVFPYL RNHSAYNIPS
     FRAGAQLLSS LSGYAYTKRA WKKEVLDLYM DPGFFQMDTS CVHWKAIIDH FLTHEKTMFK
     DLMSMPSSSL KLYSSSEQKA MLLKRQGFAV LSGEVDQYHQ YLPLIQERLT ENIRMGQTPN
     MAAQMYLFFR VLLLRISPQH LTSLWPIMVT ELIHTFVQLQ EDLMDEVPTK SSKASKHKTA
     TAEVNGTVYC EIQQSALELY LSACKFLDTA LSIPPDKMPL FQLYRWAFVP EVDTEACSVP
     SEKVENYQEC KPHVLRILEL LRFRFGEKTT EDPKWKRTEF PLLNLHSICS VTQLTPFFRT
     LGYAFKAKGE TTGESQGSEP TIEYPVEDFT KVLKELEENV ESDFLEKLGS