ID   DOPDA_XENLA             Reviewed;         118 AA.
AC   Q68FI3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=D-dopachrome decarboxylase-A;
DE            EC=4.1.1.84;
DE   AltName: Full=D-dopachrome tautomerase-A;
GN   Name=ddt-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC       5,6-dihydroxyindole (DHI). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2;
CC         Xref=Rhea:RHEA:18441, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:27404, ChEBI:CHEBI:58782; EC=4.1.1.84;
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000305}.
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DR   EMBL; BC079806; AAH79806.1; -; mRNA.
DR   RefSeq; NP_001087451.1; NM_001093982.1.
DR   AlphaFoldDB; Q68FI3; -.
DR   SMR; Q68FI3; -.
DR   DNASU; 447275; -.
DR   GeneID; 447275; -.
DR   KEGG; xla:447275; -.
DR   CTD; 447275; -.
DR   Xenbase; XB-GENE-6254136; ddt.S.
DR   OrthoDB; 1515400at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 447275; Expressed in liver and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033981; F:D-dopachrome decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; PTHR11954; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Lyase; Melanin biosynthesis; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..118
FT                   /note="D-dopachrome decarboxylase-A"
FT                   /id="PRO_0000337235"
FT   MOD_RES         2
FT                   /note="N-acetylproline"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   118 AA;  12877 MW;  74E692BFC48F1BD8 CRC64;
     MPFVELETNL PSQNVPQDLA EKLCSATATI LGKPRERVNV TVRTGVSMVV GGSSAPCTQL
     FISSIGVVGT AEQNKEHSAK FFNFLTEQLG LAQDRILLRF VPIEPWQIGK NGTIMTFL