ID   DOPD_BOVIN              Reviewed;         118 AA.
AC   A5PK65;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=D-dopachrome decarboxylase;
DE            EC=4.1.1.84 {ECO:0000250|UniProtKB:P30046};
DE   AltName: Full=D-dopachrome tautomerase;
GN   Name=DDT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC       5,6-dihydroxyindole (DHI). {ECO:0000250|UniProtKB:P30046}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2;
CC         Xref=Rhea:RHEA:18441, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:27404, ChEBI:CHEBI:58782; EC=4.1.1.84;
CC         Evidence={ECO:0000250|UniProtKB:P30046};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18442;
CC         Evidence={ECO:0000250|UniProtKB:P30046};
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:P30046}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30046}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC142376; AAI42377.1; -; mRNA.
DR   RefSeq; NP_001092620.1; NM_001099150.1.
DR   AlphaFoldDB; A5PK65; -.
DR   SMR; A5PK65; -.
DR   STRING; 9913.ENSBTAP00000029458; -.
DR   PaxDb; A5PK65; -.
DR   PRIDE; A5PK65; -.
DR   Ensembl; ENSBTAT00000029458; ENSBTAP00000029458; ENSBTAG00000022027.
DR   GeneID; 615999; -.
DR   KEGG; bta:615999; -.
DR   CTD; 1652; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022027; -.
DR   eggNOG; KOG1759; Eukaryota.
DR   GeneTree; ENSGT00940000156821; -.
DR   HOGENOM; CLU_129906_2_0_1; -.
DR   InParanoid; A5PK65; -.
DR   OMA; HSAKIFG; -.
DR   OrthoDB; 1515400at2759; -.
DR   TreeFam; TF313853; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000022027; Expressed in cortex of kidney and 106 other tissues.
DR   ExpressionAtlas; A5PK65; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0033981; F:D-dopachrome decarboxylase activity; ISS:UniProtKB.
DR   GO; GO:0050178; F:phenylpyruvate tautomerase activity; IBA:GO_Central.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; PTHR11954; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Lyase; Melanin biosynthesis; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O35215"
FT   CHAIN           2..118
FT                   /note="D-dopachrome decarboxylase"
FT                   /id="PRO_0000337233"
FT   MOD_RES         2
FT                   /note="N-acetylproline"
FT                   /evidence="ECO:0000250|UniProtKB:O35215"
FT   MOD_RES         33
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O35215"
SQ   SEQUENCE   118 AA;  12877 MW;  15C8E564BCBB8DD7 CRC64;
     MPFVELDTSL PAGRVPAGLE KRLCAATAAI LSKPEDRVNV TVRSGLAMVV NGSAEPSAQL
     LVSSIGVVGT AEENRGHSAR FFEFLTKELD LAEDRIMIRF FPLERWQIGK KGTVMTFL