ID   DOPD_XENTR              Reviewed;         118 AA.
AC   Q28J83;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=D-dopachrome decarboxylase;
DE            EC=4.1.1.84 {ECO:0000250|UniProtKB:P30046};
DE   AltName: Full=D-dopachrome tautomerase;
GN   Name=ddt; ORFNames=TNeu063o20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC       5,6-dihydroxyindole (DHI). {ECO:0000250|UniProtKB:P30046}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2;
CC         Xref=Rhea:RHEA:18441, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:27404, ChEBI:CHEBI:58782; EC=4.1.1.84;
CC         Evidence={ECO:0000250|UniProtKB:P30046};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18442;
CC         Evidence={ECO:0000250|UniProtKB:P30046};
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:P30046}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30046}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000305}.
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DR   EMBL; CR760012; CAJ83351.1; -; mRNA.
DR   EMBL; BC135935; AAI35936.1; -; mRNA.
DR   RefSeq; NP_001017261.1; NM_001017261.3.
DR   AlphaFoldDB; Q28J83; -.
DR   SMR; Q28J83; -.
DR   PaxDb; Q28J83; -.
DR   DNASU; 550015; -.
DR   Ensembl; ENSXETT00000048361; ENSXETP00000048361; ENSXETG00000022357.
DR   GeneID; 550015; -.
DR   KEGG; xtr:550015; -.
DR   CTD; 1652; -.
DR   Xenbase; XB-GENE-976099; ddt.
DR   eggNOG; KOG1759; Eukaryota.
DR   HOGENOM; CLU_129906_2_0_1; -.
DR   InParanoid; Q28J83; -.
DR   OMA; AITEFCG; -.
DR   OrthoDB; 1515400at2759; -.
DR   PhylomeDB; Q28J83; -.
DR   TreeFam; TF313853; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022357; Expressed in mesonephros and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0033981; F:D-dopachrome decarboxylase activity; ISS:UniProtKB.
DR   GO; GO:0050178; F:phenylpyruvate tautomerase activity; IBA:GO_Central.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; PTHR11954; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Lyase; Melanin biosynthesis; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O35215"
FT   CHAIN           2..118
FT                   /note="D-dopachrome decarboxylase"
FT                   /id="PRO_0000337237"
FT   MOD_RES         2
FT                   /note="N-acetylproline"
FT                   /evidence="ECO:0000250|UniProtKB:O35215"
SQ   SEQUENCE   118 AA;  12961 MW;  2E817F5D83E17885 CRC64;
     MPFVELDTNL PPQQVPQDLA EKLCSATATI LSKPRERVNV TVRTGVSMVV GGSCAPCTQL
     LVSSIGVVGT AEQNKEHSAK FFQFLTENMG LEQDRILLRF VPLEPWQVGK KATVMTFL