DOPR3_CAEBR
ID DOPR3_CAEBR Reviewed; 604 AA.
AC Q61H86; A8XC42;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Dopamine receptor 3;
GN Name=dop-3 {ECO:0000250|UniProtKB:Q6RYS9}; ORFNames=CBG10841;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Receptor for dopamine. The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase. In terms of
CC antagonist responses, would be classed with the D2-like dopamine
CC receptor group. Mediates the effect of dopamine on the inhibition of
CC locomotion. Acts as an antagonist of dop-1 (By similarity).
CC {ECO:0000250|UniProtKB:Q6RYS9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; HE601482; CAP30140.2; -; Genomic_DNA.
DR AlphaFoldDB; Q61H86; -.
DR SMR; Q61H86; -.
DR STRING; 6238.CBG10841; -.
DR PRIDE; Q61H86; -.
DR WormBase; CBG10841a; CBP43788; WBGene00032108; Cbr-dop-3.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_1_1; -.
DR InParanoid; Q61H86; -.
DR OMA; HICETHN; -.
DR OrthoDB; 1215361at2759; -.
DR Proteomes; UP000008549; Chromosome X.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..604
FT /note="Dopamine receptor 3"
FT /id="PRO_0000270581"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..520
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 542..559
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 581..604
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 399..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 95..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 604 AA; 68001 MW; 0A8E624D21C0CE85 CRC64;
MLTGQHHIPG IESPLMVVLW RVAAGVFLPL VPTMAVFGNV LVILSVYRER NLQTVTNMLI
VSLAVSDLFV AIGVMSFGVY YEWNGFKWGL GSFFCHVYQA LDVACSTASI LNLLAISLDR
YIAIGHPISY AQYGARGGRA MISITIVWGV SCAVALPLLL GVNPMENDQC ELANPWFNMI
SSIFSFFIPC IAMIILYTII FRRLRQRERA RSLRQAQRSE TDKISSALLG GAQIARQMGK
HFKNRTDQIL LEISFQTSSF PTISESSDDG STISPMINSF NNFLPKKSQY PSTLIPAIPE
CGSMPNLTII ERPAPPEKEK DIELSIMDLH DTVEMLDDKY TSAMITRSFG EELEEILPFI
DGSTSVKNSR EQLHATRSNT STTRLLDVKP ELRSISVPSI QDEKKMNSRP PENPFAHQNG
TNKQRLLPNP GILMKSKSTT LLKTNGYLDT DSLNNNRNSH KKSTADLLPN DDYSFTDSMR
VYKNRLFKSL SRATSGWNKP RPSRHMVKKA TKQMRREHKA TVTLAVVLAV FLFCWLPFFI
LHLSNSICLV IDSNSDCIGF LPLYLATWLG YLNSSLNPLI YTVFDQRFRN AFRNILSCGF
FKKR
