ID   DOT1_ARATH              Reviewed;         255 AA.
AC   Q9SIH2;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Glycine-rich protein DOT1 {ECO:0000305};
DE   AltName: Full=Protein DEFECTIVELY ORGANIZED TRIBUTARIES 1 {ECO:0000303|PubMed:18643975};
DE   Flags: Precursor;
GN   Name=DOT1 {ECO:0000303|PubMed:18643975};
GN   OrderedLocusNames=At2g36120 {ECO:0000312|Araport:AT2G36120};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=18643975; DOI=10.1111/j.1365-313x.2008.03595.x;
RA   Petricka J.J., Clay N.K., Nelson T.M.;
RT   "Vein patterning screens and the defectively organized tributaries mutants
RT   in Arabidopsis thaliana.";
RL   Plant J. 56:251-263(2008).
CC   -!- FUNCTION: Involved in leaf vasculature patterning.
CC       {ECO:0000269|PubMed:18643975}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in emerging leaf primordia and young
CC       leaves. {ECO:0000269|PubMed:18643975}.
CC   -!- DISRUPTION PHENOTYPE: Defects in venation pattern in leaves and
CC       cotyledons, post-genital organ fusions in all aerial organs from organ
CC       primordia to young expanding organs and glaucous and rough leaf
CC       surface. {ECO:0000269|PubMed:18643975}.
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DR   EMBL; AC007135; AAD26969.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09208.1; -; Genomic_DNA.
DR   EMBL; AY136328; AAM96994.1; -; mRNA.
DR   EMBL; BT000113; AAN15432.1; -; mRNA.
DR   PIR; B84777; B84777.
DR   RefSeq; NP_181156.1; NM_129171.4.
DR   AlphaFoldDB; Q9SIH2; -.
DR   STRING; 3702.AT2G36120.1; -.
DR   PaxDb; Q9SIH2; -.
DR   EnsemblPlants; AT2G36120.1; AT2G36120.1; AT2G36120.
DR   GeneID; 3768574; -.
DR   Gramene; AT2G36120.1; AT2G36120.1; AT2G36120.
DR   KEGG; ath:AT2G36120; -.
DR   Araport; AT2G36120; -.
DR   TAIR; locus:2053524; AT2G36120.
DR   eggNOG; ENOG502QU0K; Eukaryota.
DR   HOGENOM; CLU_1091263_0_0_1; -.
DR   InParanoid; Q9SIH2; -.
DR   OMA; SARGAHE; -.
DR   PRO; PR:Q9SIH2; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SIH2; baseline and differential.
DR   Genevisible; Q9SIH2; AT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.
DR   GO; GO:0048366; P:leaf development; IMP:TAIR.
DR   GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
DR   GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..255
FT                   /note="Glycine-rich protein DOT1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431314"
FT   REGION          63..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   255 AA;  19993 MW;  C661A8B1359C6120 CRC64;
     MANHKNLFFL CFLIGLGLCS ARRALLSSSE SEAEVAAYGV NSGLSAGLGV GIGGGPGGGS
     GYGGGSGEGG GAGGHGEGHI GGGGGGGHGG GAGGGGGGGP GGGYGGGSGE GGGAGYGGGE
     AGGHGGGGGG GAGGGGGGGG GAHGGGYGGG QGAGAGGGYG GGGAGGHGGG GGGGNGGGGG
     GGSGEGGAHG GGYGAGGGAG EGYGGGAGAG GHGGGGGGGG GSGGGGGGGG GYAAASGYGH
     GGGAGGGEGS GGYVP