ID   ADEC1_ALKCK             Reviewed;         576 AA.
AC   Q5WJ39;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=ABC1077;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AP006627; BAD63616.1; -; Genomic_DNA.
DR   RefSeq; WP_011245932.1; NC_006582.1.
DR   AlphaFoldDB; Q5WJ39; -.
DR   SMR; Q5WJ39; -.
DR   STRING; 66692.ABC1077; -.
DR   EnsemblBacteria; BAD63616; BAD63616; ABC1077.
DR   KEGG; bcl:ABC1077; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..576
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000142402"
SQ   SEQUENCE   576 AA;  61348 MW;  DF23D69E3742EDFC CRC64;
     MDRHHATYKK RLAAASKQEP ADILVINGKL IDVYTLTIYE ASIAITDGYI VGIGDYTEGK
     TVIDAQGKYV CPPLIDGHVH IESAMVRPED FAGVLVPKGV LTAIADPHEL ANVAGVEAVT
     YMVEAAKDLP LDIKMAVPSS VPAASFEENG ASLSAEDVRL LFANEGVYGL GEVMDYPAVL
     NGDDDMLEKI AMAKAKGRPI DGHAAGLNSD ALNAYRTAGI HNDHEAVTAE EAKARVQRGF
     YVLMREGTAA RDIEALLPAV TAANARRFAF ATDDKHLDDL LKEGSVDFNV RKAIALGMDP
     LQAIQIGTLN AAECFQLDDK GAIAPGKEAS FLFVSDLSTF QVDAVYAKGM LVAEKGELTS
     PIRTPYPVPE RLLNSVHLAP FAREDLTLKL KNAHSTPVIE TTLGSIVTKK AMASVPAENG
     IFQPGGKWLK LAVVERHEAT GHIGLAIVKG FPFSEGAIAA TVAHDSHNLI AVGADDESLY
     HAIHHVAGLG GGMAVVKGNN VLAAMPLKLG GLMSTDSAET VKQQLNELQQ SLVHLGYQEK
     IDPFLTLAFL ALPVIPALKL TSKGLFDVNA FAFVEQ