ID   DOXA1_XENLA             Reviewed;         308 AA.
AC   Q6DDK3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Dual oxidase maturation factor 1;
DE   AltName: Full=Dual oxidase activator 1;
GN   Name=duoxa1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in maturation and transport from the
CC       endoplasmic reticulum to the plasma membrane of functional dual
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DUOXA family. {ECO:0000305}.
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DR   EMBL; BC077555; AAH77555.1; -; mRNA.
DR   RefSeq; NP_001086852.1; NM_001093383.1.
DR   AlphaFoldDB; Q6DDK3; -.
DR   SMR; Q6DDK3; -.
DR   DNASU; 446687; -.
DR   GeneID; 446687; -.
DR   KEGG; xla:446687; -.
DR   CTD; 446687; -.
DR   Xenbase; XB-GENE-6255655; duoxa1.L.
DR   OrthoDB; 835845at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 446687; Expressed in zone of skin and 2 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018469; Dual_oxidase_maturation_fac.
DR   PANTHER; PTHR31158; PTHR31158; 1.
DR   Pfam; PF10204; DuoxA; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..308
FT                   /note="Dual oxidase maturation factor 1"
FT                   /id="PRO_0000264243"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..308
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        290
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  34968 MW;  98EBEAEA115673C9 CRC64;
     MQANIFPFYP QPRTPFKFDT KIIEIIIICI VTACTFIIIL PGIRGKSRSI WLLRILTSLF
     IGAVILAVNF TSDWEMGTIT ATTVYKSFSH SMLNASIGLW IGLKGLNITL IGNPEYQLNE
     TINYNEEFAW ESANQFETSY KDALERGLPF PIVYVAEKFT ISSDCGLFQQ YCISTYYSSG
     IMWIAFCSWI LYNVLFSMPV ILYGIYMMFV TAICMLVSLI SFASVRKAPV CNIQFGNSIL
     KTHFGVSYWL SLITGLLCLI ISLVLLFLYK TQPKVLQLIF SYGEEEDLSN KSENEEEHSS
     VLSLNEIL