ID   ADEC1_BRASO             Reviewed;         624 AA.
AC   A4YQV7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=BRADO2460;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CU234118; CAL76283.1; -; Genomic_DNA.
DR   RefSeq; WP_011925495.1; NC_009445.1.
DR   AlphaFoldDB; A4YQV7; -.
DR   SMR; A4YQV7; -.
DR   STRING; 114615.BRADO2460; -.
DR   EnsemblBacteria; CAL76283; CAL76283; BRADO2460.
DR   KEGG; bra:BRADO2460; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; CEASHEF; -.
DR   OrthoDB; 751534at2; -.
DR   BioCyc; BSP114615:BRADO_RS11520-MON; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..624
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000296717"
SQ   SEQUENCE   624 AA;  69153 MW;  686ECC2D012C9EE7 CRC64;
     MDLAQDIADD LMIDAAQEVR IRQDLVLTAL GHRPADRALR VGRLLDVHSR TWSEDQEIVF
     KGRRIAWVGP AGSYRGEVRE RVQRPDLAAV PGFGEVHKHI ESSHLTPEWE AALVLPRGNT
     WTCEASHEFS NVNGARNLEF WFEARRRGSP LKIFPQPGSA VPPTAYEWGG GWYGGAEQAS
     FMRESLMVTG LDEVMDWPAV WNPDNPSYER LWGMIGATFA ARGVVEGHAS GLRELPEINA
     FAAAGLASDH EVQTPEETWD KLTRGLFIEL RIYAMPEIIG WLLKKGLQDW SQIAFTTDDR
     SASHTLALGA SDHNARVAIE AGLAPEIAIQ CLTINPARHM RLTPFVGSLA PGRFGDVVLL
     SDVGKLEIAE VWADGAQVSE GTRYLGDVPR IAWPDWATQT INIKREIKAE DFALPAAPGR
     TTMQAAVIRP FHWHPEFYTF ELAVRDGAVQ RDESQAITKF AIVDRFSGDG LVSKMFWKGC
     GPRTPETALA CSVAHDKHNI WAVGSSDAAM AKAVNALVAQ QGGWALVREG ELAATVRFEV
     GGLMSCRRAE ALDAEMQALY AEGRKVDWMY EPTFRPRWYP GFPERLMFAT LTCAPWSWVL
     VAPCEQAPQG FINVQTGKTH PVVW