ID   DOXA1_XENTR             Reviewed;         308 AA.
AC   Q0P4G7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Dual oxidase maturation factor 1;
DE   AltName: Full=Dual oxidase activator 1;
GN   Name=duoxa1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in maturation and transport from the
CC       endoplasmic reticulum to the plasma membrane of functional dual
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DUOXA family. {ECO:0000305}.
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DR   EMBL; BC122088; AAI22089.1; -; mRNA.
DR   RefSeq; NP_001072563.1; NM_001079095.1.
DR   AlphaFoldDB; Q0P4G7; -.
DR   SMR; Q0P4G7; -.
DR   STRING; 8364.ENSXETP00000051522; -.
DR   PaxDb; Q0P4G7; -.
DR   Ensembl; ENSXETT00000051522; ENSXETP00000051522; ENSXETG00000023900.
DR   GeneID; 780018; -.
DR   KEGG; xtr:780018; -.
DR   CTD; 90527; -.
DR   Xenbase; XB-GENE-990812; duoxa1.
DR   eggNOG; KOG3921; Eukaryota.
DR   HOGENOM; CLU_045258_0_0_1; -.
DR   InParanoid; Q0P4G7; -.
DR   OMA; SEWFVGQ; -.
DR   OrthoDB; 835845at2759; -.
DR   PhylomeDB; Q0P4G7; -.
DR   TreeFam; TF312996; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023900; Expressed in skin of body and 1 other tissue.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018469; Dual_oxidase_maturation_fac.
DR   PANTHER; PTHR31158; PTHR31158; 1.
DR   Pfam; PF10204; DuoxA; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..308
FT                   /note="Dual oxidase maturation factor 1"
FT                   /id="PRO_0000264244"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..199
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..247
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  34937 MW;  CDF4EFD35F031DD6 CRC64;
     MQANIFPFYP QPRTSFKFDT KIIEIIIICI VTACTFIIIL PGIRGKSRSI WLFRILTSLF
     IGAVILAVNF TSDWETGIVT ATTVYKSFSH SMLNASIGLW IGLKGVNITL IGNPVYQLNE
     TINYNEEFAW ESANQFDKNY KDGLERGLPY PILYVAEKFT INSPCGLFQQ YCISTYYSSE
     IMWVAFGSWI LYNVLFSMPV ILYGICMMFV TAICMLVSLI SFASVRQAPV CNIHFGNAVL
     KTHFGVSYWL SLVTGLFCLI VSLVLLFLYK TQPKVIRLIF SYGEEEDLSD KSENEEEHSS
     ALSLNEML