ID   ADEC1_CARHZ             Reviewed;         603 AA.
AC   Q3AE90;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=CHY_0689;
OS   Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS   Z-2901).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Carboxydothermus.
OX   NCBI_TaxID=246194;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX   PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA   Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA   Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA   Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT   "Life in hot carbon monoxide: the complete genome sequence of
RT   Carboxydothermus hydrogenoformans Z-2901.";
RL   PLoS Genet. 1:563-574(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000141; ABB13729.1; -; Genomic_DNA.
DR   RefSeq; WP_011343620.1; NC_007503.1.
DR   AlphaFoldDB; Q3AE90; -.
DR   SMR; Q3AE90; -.
DR   STRING; 246194.CHY_0689; -.
DR   EnsemblBacteria; ABB13729; ABB13729; CHY_0689.
DR   KEGG; chy:CHY_0689; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; CHETTTK; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002706; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 2.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..603
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000292377"
SQ   SEQUENCE   603 AA;  65311 MW;  4E31840F8A443DC3 CRC64;
     MDAQTFKTAI VRRRLVDVLM NPELKATLVL KNGLVINVVT REIYPADVAV YDEYILKVGD
     ASDLIGPETE VVDLQGKYYV SPGFIDSHMH FESSMLTISE FSRLSIPSGT TTLVADPHEI
     GNALGPVGIK AMAEETKVVP NRVYLVVPAL TPDCPGLETA GYDITSRDMP EILNYPNVIG
     IGELQGFSNA KYVYKYTPEI ITDLIASTTY AKSIGKIVDG NAPELFGSEL AAHLIAAGTE
     ASCHETTTKE ECVEKLRYGM YVFMREGSTQ KNMAECIRAV TEEGLDSRRL IGATDDMVAE
     DLAKNGHMNW VVARIIKQGI DPVEAIQMVT INPATYFGLK HVGVLAPGKM ADIVVISDLM
     DMKVEKVYIG GKLVAEKGKM VVNIPKYTYP EEVKHSVKCK PVTAEALEIK ATGSNAVVRT
     IGLIPDQNLT ESFEFTVPVS GGVAQPDLTQ DVLPIAVVER YGRNGSIGRA FVRGFGLKGG
     AFAESVSHDA HNIIVVGTSY QDMALAVNRV IEMGGGVAVV KNGRVLGDLR LPVGGLITDE
     LDGYELSRKI AELHRLTAVE LGCTVHAPFM HLSFLALTTS PKWKITDQGL IDVNSFAIIP
     PVK