ID   ADEC1_JANSC             Reviewed;         594 AA.
AC   Q28VK7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=Jann_0338;
OS   Jannaschia sp. (strain CCS1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Jannaschia; unclassified Jannaschia.
OX   NCBI_TaxID=290400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W.,
RA   Buchan A., Gonzalez J.M., Schell M.A., Richardson P.;
RT   "Complete sequence of chromosome of Jannaschia sp. CCS1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD53255.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000264; ABD53255.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_044006214.1; NC_007802.1.
DR   AlphaFoldDB; Q28VK7; -.
DR   SMR; Q28VK7; -.
DR   STRING; 290400.Jann_0338; -.
DR   EnsemblBacteria; ABD53255; ABD53255; Jann_0338.
DR   KEGG; jan:Jann_0338; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000008326; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..594
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000292382"
SQ   SEQUENCE   594 AA;  63426 MW;  067D61344E0AF98F CRC64;
     MEPTPFPSWQ DVASALVATA AGRAPADLVI RGAKVVLVQT REVMDGWDVA IKHGRFAYVG
     PDASHCIGED TQVEELSGHY LIPGLCDGHM HIESGMLTPA EFTRAVIPHG TTSMFTDPHE
     IANVFGLRGV RLMHDEALLQ PINVFTQMPS CAPSAPGLET TGFEIGPDDV SEAMAWPGIV
     GLGEMMNFPG VVNGSQQMLA EIAATQAAGK TVGGHYASPD LGPAFHAYAA GGPADDHEGT
     SETDAMARMR QGMRSMIRLG SAWYDIESQI TAITERGLDP RNMIICTDDC FAKTLVEDGH
     MNRAVRHAID CGCDPLIALQ MATINTATHF GLEREIGQIA PGRRADMIVT RDLRTLPIEV
     VYARGQRVAQ FGECLVECPH LDWPTDTRHS VNLGKSLTAA DFEIRSDAAE VTANVIGVVE
     NQAPTKALTQ TLPVRHGVVE PDGIAQIALV ERHRGTGGVT NAFVSGFGYG PGMAMASTVA
     HDSHHMIVVG TDRAMMAKAA MRLGEVGGGI TLWQDGTERA LVELPIAGLM SDRPATEVAA
     KVTQLVEAME AAGCTLNNAY MQHSLLALVV IPELRISDLG LVDVRTFELT PVLP