ID   ADEC1_LATSS             Reviewed;         594 AA.
AC   Q38ZJ0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC1;
GN   OrderedLocusNames=LCA_0088;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CR936503; CAI54387.1; -; Genomic_DNA.
DR   RefSeq; WP_011373801.1; NC_007576.1.
DR   AlphaFoldDB; Q38ZJ0; -.
DR   SMR; Q38ZJ0; -.
DR   STRING; 314315.LCA_0088; -.
DR   EnsemblBacteria; CAI54387; CAI54387; LCA_0088.
DR   KEGG; lsa:LCA_0088; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; GHIHVEC; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..594
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000292384"
SQ   SEQUENCE   594 AA;  64210 MW;  979AC9869C493ADE CRC64;
     MIMSDRLTAF KELIQAGGAK RPADLIIKNG QLVNVMTAEI YPAEVAIYQG KIVAVDPDVS
     AYQGTETRVI DAKQQYIVPG LIDGHIHVEC SKLSMTSFAE AVVPHGTTSI ISGLDEYISV
     IGVDGLSEIF KEVDQLPMRV FWGAPFKTPY TIPASTIADN IDSTVQAQLQ KRSDVYGVWE
     TVREAVETLD EDTLKTLLNA QDNHVPVWGC APMATGTKLN EYLMSGVRVD HESYDHQELL
     EKVRKGINVV IRESSVTHFL AENIRAITET NGQIARHVSF CTDDVNAMDI VNKGHLDHLV
     RLAIAAGVAP MTAIQMATIN SAEAYRIDDQ VGLIAPGRNA DILLVSDLEA FEIKRVLAKG
     QPVATDGHIN QSIERPVRPA SLANTIIREA VQASDFEYHV AADASQVTVQ TIASEGPFVR
     HAKTKTLTVE DGIVQIDPAK DVALISVLER FGKNGNQSLG FTSGWTLKKG AMASTAAPDD
     NNIIVMGVNP DDMALAVNTL IERDGGQVVV ADGQILSFLP LPIAGIVSDV TPAELAVQEE
     GILKASQAIG SEVVDPMFYM TFLPITAIPD LAITDLGNVD CNELRLFDPI LTIQ