ID   DP71L_ASFK5             Reviewed;         185 AA.
AC   P0C754;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Protein DP71L;
DE   AltName: Full=MyD116 homolog;
GN   OrderedLocusNames=Ken-167;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with the host phosphatase PP1 catalytic subunit
CC       (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and
CC       therefore restores the host translation that has been shut-down by the
CC       host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.
CC       {ECO:0000250|UniProtKB:Q65212}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with host PPP1CB.
CC       {ECO:0000250|UniProtKB:Q65212}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the asfivirus DP71L family. {ECO:0000305}.
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DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C754; -.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0039586; P:modulation by virus of host PP1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR019523; Prot_Pase1_reg-su15A/B_C.
DR   Pfam; PF10488; PP1c_bdg; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus; Late protein;
KW   Modulation of host PP1 activity by virus; Viral immunoevasion.
FT   CHAIN           1..185
FT                   /note="Protein DP71L"
FT                   /id="PRO_0000379084"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..128
FT                   /note="Important for host CHOP inhibition"
FT                   /evidence="ECO:0000250|UniProtKB:Q65212"
FT   REGION          170..174
FT                   /note="Important for host CHOP inhibition"
FT                   /evidence="ECO:0000250|UniProtKB:Q65212"
FT   COMPBIAS        1..15
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  21506 MW;  94CA7EBC44607721 CRC64;
     MSRRNKKRSR RRRKKPLNDI QPGPSKSSAQ DEPIKSVSHH LSKIGTNPTL AFILGGNEDL
     SDDSDWDENF SLENTLMPLN EVSLNDKHNS KHFNKGFDNN TALHEVNTKW EAFYSSVKIR
     QRNVKVHFAT DDILVDVREA DDIDRKGPWE QAAVDRLRFQ RRITDTEEIL STVFLRKKLN
     PMEHE