ID   DP96R_ASFB7             Reviewed;          96 AA.
AC   Q65213;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=TBK1 inhibitor DP96R {ECO:0000305};
GN   OrderedLocusNames=Ba71V-155; ORFNames=DP96R;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [2]
RP   FUNCTION.
RC   STRAIN=China 2018/1;
RX   PubMed=30348523; DOI=10.1016/j.bbrc.2018.10.103;
RA   Wang X., Wu J., Wu Y., Chen H., Zhang S., Li J., Xin T., Jia H., Hou S.,
RA   Jiang Y., Zhu H., Guo X.;
RT   "Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China
RT   2018/1.";
RL   Biochem. Biophys. Res. Commun. 506:437-443(2018).
CC   -!- FUNCTION: Inhibits cGAS-STING-mediated type I IFN expression and NF-kB
CC       activation by inhibiting TBK1 and IKBKB/IKKB (PubMed:30348523).
CC       Inhibits host TBK1 phosphorylation (PubMed:30348523).
CC       {ECO:0000269|PubMed:30348523}.
CC   -!- SIMILARITY: Belongs to the asfivirus DP96R family. {ECO:0000305}.
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DR   EMBL; U18466; AAA65381.1; -; Genomic_DNA.
DR   RefSeq; NP_042845.1; NC_001659.2.
DR   GeneID; 22220381; -.
DR   KEGG; vg:22220381; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003670; ASFV_DP96R.
DR   Pfam; PF02512; UK; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host NF-kappa-B by virus; Inhibition of host TBK1 by virus;
KW   Inhibition of host TLR pathway by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..96
FT                   /note="TBK1 inhibitor DP96R"
FT                   /id="PRO_0000379088"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          30..96
FT                   /note="Inhibition of host cGAS-STING-TBK1 signaling
FT                   pathway"
FT                   /evidence="ECO:0000269|PubMed:30348523"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   96 AA;  10707 MW;  5748F25B0B8092C1 CRC64;
     MSTHDCFSKE KPVDMNDISE KSSVVDNAPE KPAGANHIPE KSAREMTSSE WIAEYWKGIK
     RGNDVPCCCP RKMTSADKKF SVFGKGSLIR SIQKNN