ID   DP96R_ASFP4             Reviewed;          95 AA.
AC   P0C759;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=TBK1 inhibitor DP96R {ECO:0000305};
GN   OrderedLocusNames=Pret-176;
OS   African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561443;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits cGAS-STING-mediated type I IFN expression and NF-kB
CC       activation by inhibiting TBK1 and IKBKB/IKKB (By similarity). Inhibits
CC       host TBK1 phosphorylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q65213}.
CC   -!- SIMILARITY: Belongs to the asfivirus DP96R family. {ECO:0000305}.
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DR   EMBL; AY261363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000859; Genome.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   GO; GO:0039722; P:suppression by virus of host toll-like receptor signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0039723; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003670; ASFV_DP96R.
DR   Pfam; PF02512; UK; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host NF-kappa-B by virus; Inhibition of host TBK1 by virus;
KW   Inhibition of host TLR pathway by virus; Viral immunoevasion.
FT   CHAIN           1..95
FT                   /note="TBK1 inhibitor DP96R"
FT                   /id="PRO_0000379090"
SQ   SEQUENCE   95 AA;  10689 MW;  81ACAF9EF14D2DF6 CRC64;
     MSTHNNSPKE KPVDMNNISE KLDVVNNAPE KPAGANHIPE KLAEMTSSEW IAEYWKGINR
     GNDVPCCCPR KMTSADKKFS VFGKGYLMRS MQKDD