ID   ADEC1_RHIEC             Reviewed;         565 AA.
AC   Q2K5M6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC1;
GN   OrderedLocusNames=RHE_CH03094;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000133; ABC91860.1; -; Genomic_DNA.
DR   RefSeq; WP_011426330.1; NC_007761.1.
DR   AlphaFoldDB; Q2K5M6; -.
DR   SMR; Q2K5M6; -.
DR   STRING; 347834.RHE_CH03094; -.
DR   EnsemblBacteria; ABC91860; ABC91860; RHE_CH03094.
DR   KEGG; ret:RHE_CH03094; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..565
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000292392"
SQ   SEQUENCE   565 AA;  60708 MW;  10640A1EDCDECEC0 CRC64;
     MTTKLERLID QGVGRIPADI VLKGGSFFDL VTGEIVRSDI AIGADRIVGT SGDYRGETEI
     DISGRTVVPG FIDTHLHIES SLVTPHEFDR CVLPYGVTTA ICDPHEIANV LGTEGIEFFL
     ESALETIMDI RVQLSSCVPA THLETAGADL PIERLLPFRD HPKVIGLAEF MNFPGVIHKD
     SVCMAKLDAF QGGHIDGHAP LLSGNDLNGY LSAGIRTEHE CTSAAEALEK IRKGMHILVR
     EGSVSKDLAA LIPIITERLS PYLALCTDDR NPLDIAEQGH LDHMIRTAMA SGVEPLAIYR
     AASISAARAF GLRDRGLVAP GWRADLVVLD SLQSCRAEMV FSAGRRVSDA LFATRKPVAP
     IGLDSVKARP VNAAHFGVPV AEGETSVIGV MPGKIITEHR RYRLPAKGNE TTVDLTNDII
     KVAVIERHGK NGNHANGFVQ GFGLKKGAIA STVGHDSHNI CVVGVNEDDM AYAANRLGEI
     KGGFVVVEDG KITGEIALPV AGLMSIEPYE TVRDTLHHLR QAALALGATL HEPFLQLAFL
     PLPVIPHLKI SDRGMVDVDK FALIG