DPB1_HUMAN
ID DPB1_HUMAN Reviewed; 258 AA.
AC P04440; A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0;
AC B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5; C0MPQ6; C0MPQ7;
AC C4R9J5; C5IZL1; O00259; O19698; O19700; O19702; O19749; O46884; O77952;
AC O98215; O98216; O98217; O98218; O98219; O98222; O98223; P01916; P04232;
AC P13763; P79493; P79608; Q0P0L4; Q0ZFN3; Q14279; Q27S71; Q29682; Q29684;
AC Q29698; Q29714; Q29775; Q29776; Q29778; Q29779; Q29781; Q29827; Q29828;
AC Q29879; Q29880; Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033;
AC Q30034; Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31;
AC Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51; Q5EP52;
AC Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73; Q5STP2; Q5YLA6;
AC Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6; Q6LBX7; Q6PWX6; Q6TAS4;
AC Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7; Q8HWT5; Q8SNC4; Q95HC1; Q95IT7;
AC Q95IT8; Q9BD13; Q9GIM2; Q9GIM4; Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2;
AC Q9XS11; Q9XS12;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 194.
DE RecName: Full=HLA class II histocompatibility antigen, DP beta 1 chain;
DE AltName: Full=HLA class II histocompatibility antigen, DP(W4) beta chain;
DE AltName: Full=MHC class II antigen DPB1;
DE Flags: Precursor;
GN Name=HLA-DPB1; Synonyms=HLA-DP1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01), AND NUCLEOTIDE SEQUENCE
RP [GENOMIC DNA] (ALLELES DPB1*03:01 AND DPB1*04:01).
RX PubMed=6098459; DOI=10.1002/j.1460-2075.1984.tb02245.x;
RA Kappes D.J., Arnot D., Okada K., Strominger J.L.;
RT "Structure and polymorphism of the HLA class II SB light chain genes.";
RL EMBO J. 3:2985-2993(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01).
RX PubMed=2998758; DOI=10.1002/j.1460-2075.1985.tb04012.x;
RA Tonnelle C., Demars R., Long E.O.;
RT "DO beta: a new beta chain gene in HLA-D with a distinct regulation of
RT expression.";
RL EMBO J. 4:2839-2847(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
RX PubMed=2987832; DOI=10.1093/nar/13.5.1607;
RA Kelly A., Trowsdale J.;
RT "Complete nucleotide sequence of a functional HLA-DP beta gene and the
RT region between the DP beta 1 and DP alpha 1 genes: comparison of the 5'
RT ends of HLA class II genes.";
RL Nucleic Acids Res. 13:1607-1621(1985).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
RX PubMed=3036829; DOI=10.1016/s0021-9258(18)47483-2;
RA Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H.,
RA Larhammar D., Rask L., Peterson P.A.;
RT "Class II genes of the human major histocompatibility complex. Evolution of
RT the DP region as deduced from nucleotide sequences of the four genes.";
RL J. Biol. Chem. 262:8778-8786(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*04:01).
RX PubMed=2838415; DOI=10.1016/0888-7543(88)90103-6;
RA Compagnone-Post P., Turco E., Robinson C., Trucco M.;
RT "The beta-chains of DP4 molecules from different haplotypes are encoded by
RT the same gene.";
RL Genomics 2:8-13(1988).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*01:01).
RX PubMed=1529429; DOI=10.1111/j.1399-0039.1992.tb01938.x;
RA Korioth F., Hartung K., Deicher H., Frey J.;
RT "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus.";
RL Tissue Antigens 39:216-219(1992).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*01:01; DPB1*02:02; DPB1*04:01;
RP DPB1*04:02; DPB1*05:01; DPB1*05:02; DPB1*06:02; DPB1*08:02; DPB1*09:01;
RP DPB1*09:02; DPB1*13:01; DPB1*15:01 AND DPB1*19:01).
RX PubMed=16189666; DOI=10.1007/s00251-005-0043-8;
RA Reinders J., Rozemuller E.H., van Gent R., Arts-Hilkes Y.H.,
RA van den Tweel J.G., Tilanus M.G.J.;
RT "Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing.";
RL Immunogenetics 57:790-794(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*02:02; DPB1*05:01 AND DPB1*13:01).
RA Lee E., Kim E., Kwack K.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*04:01).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*01:01).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DPB1*02:02;
RP DPB1*03:01; DPB1*04:01 AND DPB1*04:02).
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPB1*04:01).
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DPB1*01:01 AND DPB1*04:01).
RC TISSUE=B-cell, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [14]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-258 (ALLELE DPB1*04:01).
RX PubMed=2714855; DOI=10.1007/bf00352845;
RA Lee J.S., Sartoris S., Briata P., Choi E., Cullen C., Lepaslier D.,
RA Yunis I.;
RT "Sequence polymorphism of HLA-DP beta chains.";
RL Immunogenetics 29:346-349(1989).
RN [15]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-114 (ALLELE DPB1*75:01).
RA Louie L., Ginther C., Francisco A.M., van der Zwan A.W.,
RA Katongole-Mbidde E., Tilanus M.G.J., Klitz W.;
RT "HLA and mtDNA variation among the Baganda in Uganda.";
RL Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN [16]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-122 (ALLELE DPB1*56:01).
RX PubMed=7638863; DOI=10.1111/j.1399-0039.1995.tb02450.x;
RA Rani R., Fernandez-Vina M.A., Zhang S., Stastny P.;
RT "HLA-DPB1 alleles in a population from north India and description of a new
RT variant (DPB1*5601).";
RL Tissue Antigens 45:264-269(1995).
RN [17]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*39:01).
RX PubMed=1481203; DOI=10.1111/j.1399-0039.1992.tb02055.x;
RA Hessner M.J., Baxter-Lowe L.A.;
RT "Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide
RT sequencing.";
RL Tissue Antigens 40:261-263(1992).
RN [18]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*67:01).
RX PubMed=8896187; DOI=10.1111/j.1399-0039.1996.tb02637.x;
RA Meyer C.G., May J., Simon C., Bohm B.O., Loeliger C.C.;
RT "DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a
RT Turkish family.";
RL Tissue Antigens 48:231-232(1996).
RN [19]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (DPB1*77:01 AND DPB1*78:01).
RX PubMed=9756410; DOI=10.1111/j.1399-0039.1998.tb02285.x;
RA Voorter C., Richeldi L., Gervais T., van den Berg-Loonen E.;
RT "Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-
RT based typing.";
RL Tissue Antigens 52:190-192(1998).
RN [20]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*79:01).
RX PubMed=9756411; DOI=10.1111/j.1399-0039.1998.tb02286.x;
RA Voorter C., Chatelain B., Sintnicolaas K., Tilanus M.G.J., Hidajat M.,
RA van den Berg-Loonen E.;
RT "Identification of a new DPB1 allele (DPB1*7901) by sequence-based
RT typing.";
RL Tissue Antigens 52:193-195(1998).
RN [21]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*04:03).
RX PubMed=16147881; DOI=10.1080/10425170500061442;
RA Weston A., Ensey J.S., Frye B.L.;
RT "DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-
RT DPB1*0403.";
RL DNA Seq. 16:235-236(2005).
RN [22]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*98:01).
RC TISSUE=Blood;
RA Cox S.T., Wallis-Jones S.;
RT "Two new HLA DP alleles.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [23]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*20:02), AND
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*14:02).
RA Cox S.T.;
RT "Sequence of DPB1*0301 allele, and sequence of HLA-DPB1*66new.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [24]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*21:02).
RA Casanova A.A.;
RT "Sequence of DPB1*0101 variant.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [25]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*30:01;
RP DPB1*32:01; DPB1*33:01; DPB1*34:01 AND DPB1*35:01), AND NUCLEOTIDE SEQUENCE
RP [GENOMIC DNA] OF 35-121 (ALLELE DPB1*27:01).
RX PubMed=1440570; DOI=10.1111/j.1399-0039.1992.tb02109.x;
RA Moonsamy P.V., Suraj V.C., Bugawan T.L., Saiki R.K., Stoneking M.,
RA Roudier J., Magzoub M.M., Hill A.V., Begovich A.B.;
RT "Genetic diversity within the HLA class II region: ten new DPB1 alleles and
RT their population distribution.";
RL Tissue Antigens 40:153-157(1992).
RN [26]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELE DPB1*58:01).
RX PubMed=7806296; DOI=10.1007/bf00182337;
RA Versluis L.F., van der Zwan A.W., Tilanus M.G.J., Daly L.N.,
RA Degli-Eposti M.A., Dawkins R.L.;
RT "Identification of the novel HLA-DPB1*5801 allele detected by sequenced
RT based typing.";
RL Immunogenetics 41:173-173(1995).
RN [27]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*60:01 AND
RP DPB1*62:01).
RX PubMed=8773318; DOI=10.1111/j.1399-0039.1996.tb02556.x;
RA Zimmerman P.A., Steiner L.L., Titanji V.P., Nde P.N., Bradley J.E.,
RA Pogonka T., Begovich A.B.;
RT "Three new DPB1 alleles identified in a Bantu-speaking population from
RT central Cameroon.";
RL Tissue Antigens 47:293-299(1996).
RN [28]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 35-258, AND VARIANTS LEU-94; VAL-105;
RP ASP-113; GLU-114; ALA-115; VAL-116; LYS-125 AND ILE-199.
RX PubMed=6330724; DOI=10.1073/pnas.81.13.3934;
RA Gorski J., Rollini P., Long E., Mach B.;
RT "Molecular organization of the HLA-SB region of the human major
RT histocompatibility complex and evidence for two SB beta-chain genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:3934-3938(1984).
RN [29]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELE DPB1*24:02).
RX PubMed=19775376; DOI=10.1111/j.1399-0039.2009.01325.x;
RA Witter K., Kirchner E., Borelli C., Messer G., Albert T., Zahn R.,
RA Kauke T.;
RT "In a study for acne vulgaris, sequence-based HLA typing showed a novel
RT DPB1 allele, DPB1*2402.";
RL Tissue Antigens 74:354-356(2009).
RN [30]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELES DPB1*06:01;
RP DPB1*16:01; DPB1*17:01; DPB1*18:01; DPB1*20:01; DPB1*23:01; DPB1*26:01;
RP DPB1*26:02; DPB1*28:01; DPB1*45:01; DPB1*55:01; DPB1*85:01 AND DPB1*88:01).
RA Witter K., Tran H., Sabine S.;
RT "Confirmation of several HLA-DPB1 alleles including exon 3.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [31]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01).
RX PubMed=2460556;
RA Bugawan T.L., Horn G.T., Long C.M., Mickelson E., Hansen J.A.,
RA Ferrara G.B., Angelini G., Erlich H.A.;
RT "Analysis of HLA-DP allelic sequence polymorphism using the in vitro
RT enzymatic DNA amplification of DP-alpha and DP-beta loci.";
RL J. Immunol. 141:4024-4030(1988).
RN [32]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01), AND
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*08:01).
RX PubMed=2242906; DOI=10.1007/bf00187094;
RA Bugawan T.L., Begovich A.B., Erlich H.A.;
RT "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive
RT sequence-specific oligonucleotide probes.";
RL Immunogenetics 32:231-241(1990).
RN [33]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*46:01).
RC TISSUE=Leukocyte;
RX PubMed=8344726; DOI=10.1007/bf00210483;
RA Buyse I., Emonds M.P., Bouillon R., Marynen P., Cassiman J.J.;
RT "Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian
RT population.";
RL Immunogenetics 38:380-380(1993).
RN [34]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*41:01).
RX PubMed=7901923; DOI=10.1111/j.1399-0039.1993.tb02016.x;
RA Mizuki N., Ohno S., Sugimura K., Seki T., Ishioka M., Inoko H., Geng L.;
RT "Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its
RT nucleotide sequence determination by direct sequencing after PCR
RT amplification.";
RL Tissue Antigens 41:259-262(1993).
RN [35]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*47:01).
RC TISSUE=Blood;
RX PubMed=7912859; DOI=10.1111/j.1399-0039.1994.tb02297.x;
RA Koshizaka T., Taguchi M., Onishi H., Kobayashi S., Inoko H.;
RT "A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701).";
RL Tissue Antigens 43:50-53(1994).
RN [36]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*51:01).
RC TISSUE=Blood;
RX PubMed=7839356; DOI=10.1111/j.1399-0039.1994.tb02382.x;
RA Kaneshige T., Kinoshita T., Hashimoto M., Matsumoto Y., Moribe T.,
RA Ichikawa Y., Fukunishi T., Uchida K.;
RT "Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote
RT from the membrane of reverse dot blot analysis.";
RL Tissue Antigens 44:204-207(1994).
RN [37]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*66:01).
RC TISSUE=Blood;
RX PubMed=8781129; DOI=10.1007/bf02602788;
RA Schnittger L., May J., Kretschmer C., Kremsner P.G., Meyer C.G.;
RT "DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin.";
RL Immunogenetics 44:405-406(1996).
RN [38]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*65:01).
RX PubMed=8824162; DOI=10.1007/bf02602812;
RA Versluis L.F., Philippe M., Van der Zwan A., Thonnard J., Tongio M.M.,
RA Tilanus M.G.J.;
RT "Identification of a new HLA-DPB1*6501 allele in a Caucasian individual.";
RL Immunogenetics 44:483-484(1996).
RN [39]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*82:01 AND
RP DPB1*83:01).
RX PubMed=11169249; DOI=10.1034/j.1399-0039.2000.560613.x;
RA Voorter C., Tilanus M.G.J., van den Berg-Loonen E.;
RT "Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201
RT and DPB1*8301.";
RL Tissue Antigens 56:560-562(2000).
RN [40]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*86:01).
RX PubMed=11556983; DOI=10.1034/j.1399-0039.2001.057006536.x;
RA Bengtsson M.;
RT "DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid
RT population.";
RL Tissue Antigens 57:536-539(2001).
RN [41]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*87:01).
RX PubMed=11782281; DOI=10.1034/j.1399-0039.2001.580410.x;
RA Grams S.E., Wu J., Noreen H.J., Mangaccat J., Cognato M.A., Johnson S.,
RA Segall M., Williams T.M., Begovich A.B.;
RT "Three new DP alleles identified in a study of 800 unrelated bone marrow
RT donor-recipient pairs.";
RL Tissue Antigens 58:272-275(2001).
RN [42]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*90:01).
RX PubMed=12135440; DOI=10.1034/j.1399-0039.2002.590419.x;
RA Bengtsson M., Danielsson F., Jansson I.E., Johansson U.;
RT "Identification of a new HLA-DPB1 allele,HLA-DPB1*9001.";
RL Tissue Antigens 59:344-346(2002).
RN [43]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*93:01).
RX PubMed=12694578; DOI=10.1046/j.0001-2815.2002.00143.x;
RA Liu Z.-H., Fan X., Lin J., Fu Y., Liu X., Xu A.;
RT "Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing
RT in a Lahu ethnic minority of China.";
RL Tissue Antigens 61:261-262(2003).
RN [44]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*94:01 AND
RP DPB1*95:01).
RX PubMed=12890000; DOI=10.1034/j.1399-0039.2003.00066.x;
RA Luo M., Ramdahin S., Iqbal S., Pan Y., Jacobson K., Narayansingh M.J.,
RA Schroeder M., Brunham R.C., Embree J., Plummer F.A.;
RT "High resolution sequence-based DPB1 typing identified two novel DPB1
RT alleles, DPB1*9401 and DPB1*9501, from a Kenyan population.";
RL Tissue Antigens 62:182-184(2003).
RN [45]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (DPB1*96:01).
RX PubMed=12890001; DOI=10.1034/j.1399-0039.2003.00081.x;
RA Witter K., Gervais T., Dunn P.P., Voorter C., Muramoto J., Albert E.D.;
RT "Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601.";
RL Tissue Antigens 62:185-187(2003).
RN [46]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*01:02).
RX PubMed=15361132; DOI=10.1111/j.1399-0039.2004.00276.x;
RA Lv F., Lin J., Liu Z.-H., Gao J., Fu Y., Xu A.;
RT "Identification of a novel HLA-DPB1 allele--DPB1*0102.";
RL Tissue Antigens 64:512-514(2004).
RN [47]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*17:02).
RC TISSUE=Blood;
RX PubMed=16866899; DOI=10.1111/j.1399-0039.2006.00630.x;
RA Li M., Nie J., Xu Y., Xu A., Yu X.;
RT "Identification of a novel HLA-DPB1 allele, DPB1*1702.";
RL Tissue Antigens 68:187-188(2006).
RN [48]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*21:01;
RP DPB1*22:01; DPB1*24:01; DPB1*25:01; DPB1*29:01 AND DPB1*31:01).
RA Kimura A.;
RL Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN [49]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*89:01).
RA Dormoy A., Routoulp M., Froelich N., Tongio M.M.;
RT "A new HLA-DPB1* allele identical to the DPB1*0101 allele except for the
RT polymorphic positions 226 and 228 where G and A are found respectively in
RT place of A and G.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [50]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*91:01 AND
RP DPB1*92:01).
RA Varney M.D., Rossi V.;
RT "A novel DPB1 allele.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [51]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*10:01).
RA Luo M., Mao X., Shehzad I., Jacobson K., Kwan L., Shroeder M.,
RA Plummer F.A.;
RT "Sequence-based DPB typing fills the missing exon 2 sequences of multiple
RT HLA-DPB1 alleles.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [52]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*99:01).
RA Edelshtein D., Sidebottom D., Chen D.-F., Baxter-Lowe L.A.;
RT "A novel DPB1 allele identified by sequence-based typing and Confirmed by
RT SSP.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [53]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*02:03).
RA Wu J., Williams T.M., Cognato M.A.;
RT "Novel human HLA-DPB1 allele identified in potential bone marrow donors.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [54]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*10:02 AND
RP DPB1*11:02).
RA Garbarino L., Chiesa A., Pastori F., Sacchi N., Cusano R., Bottero F.,
RA Bossi R.;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [55]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*13:02).
RA Moonsamy P.V., Bonella P.L., Sali P.J., Bentley L.G., Post J.L.,
RA Goodwin G., Erlich H.E.;
RT "The identification of a new DPB1 allele in a type 1 diabetes genetics
RT consortium family.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [56]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*16:02).
RA Kashiwase K., Ichihara T., Shimizu M., Satake M.;
RT "HLA-DPB1*8601V1.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [57]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*18:02).
RA Cordovado S.K., Hancock L.N., Mueller P.W.;
RT "Identification of a novel DPB1 allele by sequence-based typing in the
RT GoKinD population.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [58]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*19:02).
RA Monos D.S.;
RT "A New HLA-DPB1 allele.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [59]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*11:01).
RC TISSUE=Peripheral blood;
RA Vilches C.;
RT "Complete exon 2 sequence of the HLA-DPB1*110101 allele.";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [60]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*22:02).
RC TISSUE=Peripheral blood;
RA McWhinnie A.J.M., Wallis-Jones S., Little A.M.;
RT "Exon 2 sequence of a new HLA-DPB1 allele DPB1*XX exhibiting single
RT nucleotide difference G337A from HLA-DPB1*1401.";
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [61]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*25:02).
RA Lazaro A.M., Xiao Y., Nehlsen-Cannarella S.L., Fagoaga O.R., Hurley C.K.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN [62]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*40:01;
RP DPB1*48:01; DPB1*49:01; DPB1*50:01; DPB1*51:01; DPB1*52:01 AND DPB1*53:01).
RX PubMed=8085260; DOI=10.1111/j.1399-0039.1994.tb02333.x;
RA Moonsamy P.V., Aldrich C.L., Petersdorf E.W., Hill A.V., Begovich A.B.;
RT "Seven new DPB1 alleles and their population distribution.";
RL Tissue Antigens 43:249-252(1994).
RN [63]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*59:01;
RP DPB1*68:01; DPB1*70:01; DPB1*71:01; DPB1*72:01 AND DPB1*73:01).
RX PubMed=9174146; DOI=10.1111/j.1399-0039.1997.tb02788.x;
RA Noreen H.J., Steiner L.L., Davidson M., Johnson S., Segall M.,
RA Begovich A.B.;
RT "Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow
RT donor-recipient pairs.";
RL Tissue Antigens 49:512-516(1997).
RN [64]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*80:01), AND
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*81:01).
RX PubMed=10090623; DOI=10.1034/j.1399-0039.1999.530213.x;
RA Steiner L.L., Wu J., Noreen H.J., Moehlenkamp C., Cavalli A.S.,
RA Davidson M., Johnson S., Winden T., Segall M., Begovich A.B.,
RA Williams T.M.;
RT "Four new DP alleles identified in a study of 500 unrelated bone marrow
RT donor-recipient pairs.";
RL Tissue Antigens 53:201-206(1999).
RN [65]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*97:01).
RX PubMed=15140044; DOI=10.1111/j.0001-2815.2004.00198.x;
RA Lapi S., Curcio M., Fornaciari S., Mariotti M.L., Isola P., Bonci F.,
RA Pistello M., Scatena F.;
RT "Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based
RT typing.";
RL Tissue Antigens 63:606-608(2004).
RN [66]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*63:01).
RA Begovich A.B., Steiner L.L.;
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN [67]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*76:01).
RA Rozemuller E.H.;
RT "A new HLA-DPB1 allele: a variant of DPB1*1401.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [68]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*44:01).
RX PubMed=7744621; DOI=10.1016/0198-8859(94)00100-5;
RA Versluis L.F., Tilanus M.G.J., Verduyn W., Abdulkadir J., Giphart M.J.;
RT "Novel HLA-DPB1 alleles detected in the Ethiopian population.";
RL Hum. Immunol. 42:181-183(1995).
RN [69]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*59:01).
RX PubMed=8851734; DOI=10.1111/j.1399-0039.1996.tb02533.x;
RA Noble J.A., Cavalli A.S., Erlich H.A.;
RT "DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-
RT dependent diabetes mellitus.";
RL Tissue Antigens 47:159-162(1996).
RN [70]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*03:02).
RX PubMed=15982263; DOI=10.1111/j.1399-0039.2005.00429.x;
RA Sheldon M.H., Azzaro M.P., Sayer D., Bunce M., Sortino G.;
RT "Identification of a new allele in a Sicilian individual: HLA-DPB1*0302.";
RL Tissue Antigens 66:64-66(2005).
RN [71]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*69:01).
RA Varney M.D., Tait B.D.;
RT "Identification of a novel DPB allele.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [72]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-114 (ALLELE DPB1*44:01).
RC TISSUE=Blood;
RA Easteal S., Croft L.;
RT "A new HLA-DPB1 alleles from Santa Cruz Island, Solomon Islands.";
RL Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
RN [73]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*37:01).
RX PubMed=1412421; DOI=10.1111/j.1399-0039.1992.tb01966.x;
RA Meyer C.G., Schnittger L., Begovich A.B., Erlich H.A., Horstmann R.D.;
RT "DPB1*WA4 - an additional HLA class II allele identified in west Africa.";
RL Tissue Antigens 40:98-99(1992).
RN [74]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*38:01).
RX PubMed=1358867; DOI=10.1016/0198-8859(92)90113-2;
RA Mitsunaga S., Kuwata S., Tokunaga K., Uchikawa C., Takahashi K., Akaza T.,
RA Mitomi Y., Juji T.;
RT "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and
RT two 'new' alleles.";
RL Hum. Immunol. 34:203-211(1992).
RN [75]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*36:01).
RX PubMed=7817379; DOI=10.1111/j.1399-0039.1994.tb02370.x;
RA Ogawa K., Itho H., Nakajyo S., Kobayashi K., Sekiguchi S., Koshizaka T.,
RA Taguchi M., Onishi H., Kobayashi S., Inoko H.;
RT "A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT).";
RL Tissue Antigens 44:134-136(1994).
RN [76]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*74:01).
RX PubMed=9694359; DOI=10.1111/j.1399-0039.1998.tb03009.x;
RA Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P.,
RA Bradley J.E., Lucius R., Nutman T.B., Begovich A.B.;
RT "Three new DP alleles identified in sub-Saharan Africa: DPB1*7401,
RT DPA1*02013, and DPA1*0302.";
RL Tissue Antigens 51:653-657(1998).
RN [77]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-115 (ALLELE DPB1*57:01).
RC TISSUE=Lymphocyte;
RX PubMed=8525482; DOI=10.1111/j.1399-0039.1995.tb03122.x;
RA Mersch G., Mytilineos J., De Canck I., Deufel A., Mijs W., Scherer S.,
RA Jannes G., Opelz G., Rossau R.;
RT "Characterization of a new DPB1 allele (DPB1*5701) isolated from a
RT Caucasian individual.";
RL Tissue Antigens 46:208-212(1995).
RN [78]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-121 (ALLELE DPB1*84:01).
RX PubMed=10958363; DOI=10.1034/j.1399-0039.2000.560114.x;
RA McTernan C.L., Mijovic C.H., Cockram C.S., Barnett A.H.;
RT "The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401,
RT identified in a Chinese subject.";
RL Tissue Antigens 56:95-98(2000).
RN [79]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 78-258 (ALLELE DPB1*02:01).
RX PubMed=6310612; DOI=10.1073/pnas.80.19.6036;
RA Roux-Dosseto M., Auffray C., Lillie J.W., Boss J.M., Cohen D., Demars R.,
RA Mawas C., Seidman J.G., Strominger J.L.;
RT "Genetic mapping of a human class II antigen beta-chain cDNA clone to the
RT SB region of the HLA complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 80:6036-6040(1983).
RN [80]
RP REVIEW.
RX PubMed=8598037; DOI=10.1016/s0092-8674(00)81025-9;
RA Cresswell P.;
RT "Invariant chain structure and MHC class II function.";
RL Cell 84:505-507(1996).
RN [81]
RP REVIEW.
RX PubMed=11684289; DOI=10.1016/s0161-5890(01)00069-4;
RA Villadangos J.A.;
RT "Presentation of antigens by MHC class II molecules: getting the most out
RT of them.";
RL Mol. Immunol. 38:329-346(2001).
RN [82]
RP REVIEW.
RX PubMed=18046453; DOI=10.1038/sj.emboj.7601945;
RA Rocha N., Neefjes J.;
RT "MHC class II molecules on the move for successful antigen presentation.";
RL EMBO J. 27:1-5(2008).
RN [83]
RP REVIEW.
RX PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005;
RA Menendez-Benito V., Neefjes J.;
RT "Autophagy in MHC class II presentation: sampling from within.";
RL Immunity 26:1-3(2007).
RN [84]
RP REVIEW.
RX PubMed=19092054; DOI=10.1242/jcs.035089;
RA Berger A.C., Roche P.A.;
RT "MHC class II transport at a glance.";
RL J. Cell Sci. 122:1-4(2009).
RN [85]
RP REVIEW.
RX PubMed=19533806; DOI=10.3748/wjg.15.2855;
RA Beswick E.J., Reyes V.E.;
RT "CD74 in antigen presentation, inflammation, and cancers of the
RT gastrointestinal tract.";
RL World J. Gastroenterol. 15:2855-2861(2009).
CC -!- FUNCTION: Binds peptides derived from antigens that access the
CC endocytic route of antigen presenting cells (APC) and presents them on
CC the cell surface for recognition by the CD4 T-cells. The peptide
CC binding cleft accommodates peptides of 10-30 residues. The peptides
CC presented by MHC class II molecules are generated mostly by degradation
CC of proteins that access the endocytic route, where they are processed
CC by lysosomal proteases and other hydrolases. Exogenous antigens that
CC have been endocytosed by the APC are thus readily available for
CC presentation via MHC II molecules, and for this reason this antigen
CC presentation pathway is usually referred to as exogenous. As membrane
CC proteins on their way to degradation in lysosomes as part of their
CC normal turn-over are also contained in the endosomal/lysosomal
CC compartments, exogenous antigens must compete with those derived from
CC endogenous components. Autophagy is also a source of endogenous
CC peptides, autophagosomes constitutively fuse with MHC class II loading
CC compartments. In addition to APCs, other cells of the gastrointestinal
CC tract, such as epithelial cells, express MHC class II molecules and
CC CD74 and act as APCs, which is an unusual trait of the GI tract. To
CC produce a MHC class II molecule that presents an antigen, three MHC
CC class II molecules (heterodimers of an alpha and a beta chain)
CC associate with a CD74 trimer in the ER to form a heterononamer. Soon
CC after the entry of this complex into the endosomal/lysosomal system
CC where antigen processing occurs, CD74 undergoes a sequential
CC degradation by various proteases, including CTSS and CTSL, leaving a
CC small fragment termed CLIP (class-II-associated invariant chain
CC peptide). The removal of CLIP is facilitated by HLA-DM via direct
CC binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM
CC stabilizes MHC class II molecules until primary high affinity antigenic
CC peptides are bound. The MHC II molecule bound to a peptide is then
CC transported to the cell membrane surface. In B-cells, the interaction
CC between HLA-DM and MHC class II molecules is regulated by HLA-DO.
CC Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal
CC microenvironment has been implicated in the regulation of antigen
CC loading into MHC II molecules, increased acidification produces
CC increased proteolysis and efficient peptide loading.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred as
CC MHC class II molecule. In the endoplasmic reticulum (ER) it forms a
CC heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also
CC known as invariant chain or HLA class II histocompatibility antigen
CC gamma chain). In the endosomal/lysosomal system; CD74 undergoes
CC sequential degradation by various proteases; leaving a small fragment
CC termed CLIP on each MHC class II molecule. MHC class II molecule
CC interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP
CC and facilitate the binding of antigenic peptides.
CC -!- INTERACTION:
CC P04440; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-2802503, EBI-16439278;
CC P04440; Q96CV9: OPTN; NbExp=3; IntAct=EBI-2802503, EBI-748974;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Endoplasmic reticulum membrane; Single-pass type I membrane
CC protein. Golgi apparatus, trans-Golgi network membrane; Single-pass
CC type I membrane protein. Endosome membrane; Single-pass type I membrane
CC protein. Lysosome membrane; Single-pass type I membrane protein.
CC Note=The MHC class II complex transits through a number of
CC intracellular compartments in the endocytic pathway until it reaches
CC the cell membrane for antigen presentation.
CC -!- POLYMORPHISM: The following alleles of HLA-DPB1 are known: DPB1*01:01,
CC DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02,
CC DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01,
CC DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01,
CC DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01,
CC DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01,
CC DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01,
CC DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01,
CC DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02,
CC DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01,
CC DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01,
CC DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01,
CC DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01,
CC DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01,
CC DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
CC DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01,
CC DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01,
CC DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01,
CC DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01,
CC DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01,
CC DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of
CC DPB1*04:01.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ12564.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X01426; CAA25672.1; -; mRNA.
DR EMBL; X02964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X03023; CAE82008.1; -; Genomic_DNA.
DR EMBL; X03024; CAE82007.1; -; Genomic_DNA.
DR EMBL; X03022; CAA26823.1; -; Genomic_DNA.
DR EMBL; X03025; CAE82037.1; -; Genomic_DNA.
DR EMBL; X03026; CAE82042.1; -; Genomic_DNA.
DR EMBL; X03028; CAE82073.1; -; Genomic_DNA.
DR EMBL; X03027; CAE82043.1; -; Genomic_DNA.
DR EMBL; X03067; CAA26871.1; -; mRNA.
DR EMBL; X02228; CAA26147.1; -; Genomic_DNA.
DR EMBL; J03041; AAA35993.1; -; mRNA.
DR EMBL; M83664; AAA59837.1; -; mRNA.
DR EMBL; AY804132; AAW78737.1; -; mRNA.
DR EMBL; AY804133; AAW78738.1; -; mRNA.
DR EMBL; AY804135; AAW78740.1; -; mRNA.
DR EMBL; AY804136; AAW78741.1; -; mRNA.
DR EMBL; AY804137; AAW78742.1; -; mRNA.
DR EMBL; AY804138; AAW78743.1; -; mRNA.
DR EMBL; AY804139; AAW78744.1; -; mRNA.
DR EMBL; AY804141; AAW78746.1; -; mRNA.
DR EMBL; AY804142; AAW78747.1; -; mRNA.
DR EMBL; AY804143; AAW78748.1; -; mRNA.
DR EMBL; AY831401; AAW80919.1; -; mRNA.
DR EMBL; AY831402; AAW80920.1; -; mRNA.
DR EMBL; AY831403; AAW80921.1; -; mRNA.
DR EMBL; AY831404; AAW80922.1; -; mRNA.
DR EMBL; AY656678; AAV71025.1; -; mRNA.
DR EMBL; AY656679; AAV71026.1; -; mRNA.
DR EMBL; AY656680; AAV71027.1; -; mRNA.
DR EMBL; AK313305; BAG36110.1; -; mRNA.
DR EMBL; BT019780; AAV38583.1; -; mRNA.
DR EMBL; AL645931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX120009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR762479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03674.1; -; Genomic_DNA.
DR EMBL; BC007963; AAH07963.1; -; mRNA.
DR EMBL; BC013184; AAH13184.1; -; mRNA.
DR EMBL; M28202; AAA53197.1; -; mRNA.
DR EMBL; Y09327; CAA70507.1; -; Genomic_DNA.
DR EMBL; L31816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M97686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X96985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Y13900; CAA74199.1; -; Genomic_DNA.
DR EMBL; Y14230; CAA74608.1; -; Genomic_DNA.
DR EMBL; Y16095; CAA76060.1; -; Genomic_DNA.
DR EMBL; AY823995; AAW79272.1; -; Genomic_DNA.
DR EMBL; AJ563603; CAD91639.1; -; Genomic_DNA.
DR EMBL; AM039828; CAJ01690.1; -; Genomic_DNA.
DR EMBL; AM408787; CAL64063.1; -; Genomic_DNA.
DR EMBL; AM698036; CAM91695.1; -; Genomic_DNA.
DR EMBL; M84619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M84626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X82123; CAA57635.1; -; Genomic_DNA.
DR EMBL; U22311; AAB60413.1; -; Genomic_DNA.
DR EMBL; U22313; AAB17108.1; -; Genomic_DNA.
DR EMBL; K01615; AAA36313.1; -; mRNA.
DR EMBL; FM883600; CAT04585.2; -; Genomic_DNA.
DR EMBL; FM882212; CAT03206.1; -; Genomic_DNA.
DR EMBL; FM956650; CAX11690.1; -; Genomic_DNA.
DR EMBL; FM991729; CAX20314.1; -; Genomic_DNA.
DR EMBL; FM992080; CAX21583.2; -; Genomic_DNA.
DR EMBL; FM992366; CAX30407.1; -; Genomic_DNA.
DR EMBL; FM992364; CAX30405.1; -; Genomic_DNA.
DR EMBL; FN252853; CAX53275.1; -; Genomic_DNA.
DR EMBL; FN256250; CAX53717.1; -; Genomic_DNA.
DR EMBL; FN256251; CAX53721.1; -; Genomic_DNA.
DR EMBL; FN256254; CAX53718.1; -; Genomic_DNA.
DR EMBL; FN256253; CAX53726.1; -; Genomic_DNA.
DR EMBL; FN256255; CAX53722.1; -; Genomic_DNA.
DR EMBL; FN393829; CAY85528.1; -; Genomic_DNA.
DR EMBL; M23675; AAA59740.1; -; Genomic_DNA.
DR EMBL; M62326; AAA59719.1; -; Genomic_DNA.
DR EMBL; M62331; AAA59724.1; -; Genomic_DNA.
DR EMBL; L07768; AAA59690.1; -; Genomic_DNA.
DR EMBL; D13174; BAA02465.1; -; Genomic_DNA.
DR EMBL; D10834; BAA01614.1; -; Genomic_DNA.
DR EMBL; D28809; BAA05970.1; -; Genomic_DNA.
DR EMBL; X96986; CAA65710.2; -; Genomic_DNA.
DR EMBL; X91886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Y18498; CAC12860.1; -; Genomic_DNA.
DR EMBL; AJ238005; CAC12865.1; -; Genomic_DNA.
DR EMBL; AJ271373; CAB70605.2; -; Genomic_DNA.
DR EMBL; AF288354; AAG30143.1; -; Genomic_DNA.
DR EMBL; AJ292074; CAC27995.1; -; Genomic_DNA.
DR EMBL; AF536241; AAN33050.1; -; Genomic_DNA.
DR EMBL; AF549409; AAQ12563.1; -; Genomic_DNA.
DR EMBL; AF549410; AAQ12564.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AJ514871; CAD55852.1; -; Genomic_DNA.
DR EMBL; AY374100; AAR21105.1; -; Genomic_DNA.
DR EMBL; DQ206450; ABB17974.1; -; Genomic_DNA.
DR EMBL; M83914; AAA36264.1; -; Genomic_DNA.
DR EMBL; M83915; AAA36259.1; -; Genomic_DNA.
DR EMBL; M83916; AAA36260.1; -; Genomic_DNA.
DR EMBL; M83917; AAA36261.1; -; Genomic_DNA.
DR EMBL; M83918; AAA36262.1; -; Genomic_DNA.
DR EMBL; M83919; AAA36263.1; -; Genomic_DNA.
DR EMBL; AJ297820; CAC14048.1; -; Genomic_DNA.
DR EMBL; AY029777; AAK40344.1; -; Genomic_DNA.
DR EMBL; AF489518; AAL92172.1; -; Genomic_DNA.
DR EMBL; AF492640; AAO84765.1; -; Genomic_DNA.
DR EMBL; AY425707; AAR29060.1; -; Genomic_DNA.
DR EMBL; AY572830; AAS77869.1; -; Genomic_DNA.
DR EMBL; AY855160; AAW33682.1; -; Genomic_DNA.
DR EMBL; AY855161; AAW33683.1; -; Genomic_DNA.
DR EMBL; DQ089022; AAY98352.1; -; Genomic_DNA.
DR EMBL; AB247517; BAE78492.1; -; Genomic_DNA.
DR EMBL; DQ386161; ABD36812.1; -; Genomic_DNA.
DR EMBL; DQ485789; ABF47047.1; -; Genomic_DNA.
DR EMBL; AM887530; CAP08783.1; -; Genomic_DNA.
DR EMBL; FM211032; CAR66500.1; -; Genomic_DNA.
DR EMBL; FJ976693; ACS12738.1; -; Genomic_DNA.
DR EMBL; L17310; AAA53479.1; -; Genomic_DNA.
DR EMBL; L17311; AAA53480.1; -; Genomic_DNA.
DR EMBL; L17313; AAA53481.1; -; Genomic_DNA.
DR EMBL; L17314; AAA53482.1; -; Genomic_DNA.
DR EMBL; L22076; AAA53476.1; -; Genomic_DNA.
DR EMBL; L22077; AAA53477.1; -; Genomic_DNA.
DR EMBL; L23400; AAA58441.1; -; Genomic_DNA.
DR EMBL; U59437; AAD09481.1; -; Genomic_DNA.
DR EMBL; U59438; AAD09482.1; -; Genomic_DNA.
DR EMBL; U59439; AAD09483.1; -; Genomic_DNA.
DR EMBL; U59440; AAD09484.1; -; Genomic_DNA.
DR EMBL; U59441; AAD09485.1; -; Genomic_DNA.
DR EMBL; U59442; AAD09486.1; -; Genomic_DNA.
DR EMBL; AF074845; AAD39682.1; -; Genomic_DNA.
DR EMBL; AF074846; AAD39683.1; -; Genomic_DNA.
DR EMBL; AY033075; AAK51161.1; -; Genomic_DNA.
DR EMBL; U34033; AAA81335.1; -; Genomic_DNA.
DR EMBL; Z92523; CAB06822.1; -; Genomic_DNA.
DR EMBL; X78042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U29534; AAB52511.1; -; Genomic_DNA.
DR EMBL; AY618897; AAT40308.1; -; Genomic_DNA.
DR EMBL; X97406; CAA66059.1; -; Genomic_DNA.
DR EMBL; L01466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M87046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; D10478; BAA01281.1; -; Genomic_DNA.
DR EMBL; D10882; BAA01704.1; -; Genomic_DNA.
DR EMBL; U94839; AAC64232.1; -; Genomic_DNA.
DR EMBL; X80752; CAA56728.1; -; Genomic_DNA.
DR EMBL; AF077015; AAC26835.1; -; Genomic_DNA.
DR EMBL; K00409; AAA36312.1; -; mRNA.
DR CCDS; CCDS4765.1; -.
DR PIR; A02228; HLHUS1.
DR PIR; A02229; HLHUPB.
DR PIR; D30536; D30536.
DR PIR; D30537; D30537.
DR PIR; E30536; E30536.
DR PIR; I37298; I37298.
DR PIR; I37541; S49382.
DR PIR; I38195; HLHUS2.
DR PIR; I38197; I38197.
DR PIR; I59621; I59621.
DR PIR; I59637; I59637.
DR PIR; I59641; I59641.
DR PIR; I81234; I81234.
DR PIR; I81235; I81235.
DR PIR; I81236; I81236.
DR PIR; I81237; I81237.
DR PIR; I81238; I81238.
DR RefSeq; NP_002112.3; NM_002121.5.
DR PDB; 3LQZ; X-ray; 3.25 A; B=33-218.
DR PDB; 4P4K; X-ray; 2.80 A; B/F=32-218.
DR PDB; 4P4R; X-ray; 3.00 A; B/D=32-218.
DR PDB; 4P57; X-ray; 2.60 A; B/D=33-218.
DR PDB; 4P5K; X-ray; 2.59 A; B/E=33-218.
DR PDB; 4P5M; X-ray; 1.70 A; B/D/F/H=33-218.
DR PDBsum; 3LQZ; -.
DR PDBsum; 4P4K; -.
DR PDBsum; 4P4R; -.
DR PDBsum; 4P57; -.
DR PDBsum; 4P5K; -.
DR PDBsum; 4P5M; -.
DR AlphaFoldDB; P04440; -.
DR SMR; P04440; -.
DR BioGRID; 109360; 111.
DR IntAct; P04440; 25.
DR MINT; P04440; -.
DR STRING; 9606.ENSP00000408146; -.
DR GlyConnect; 1366; 7 N-Linked glycans (1 site).
DR GlyGen; P04440; 1 site, 7 N-linked glycans (1 site).
DR iPTMnet; P04440; -.
DR PhosphoSitePlus; P04440; -.
DR SwissPalm; P04440; -.
DR BioMuta; HLA-DPB1; -.
DR DMDM; 122263; -.
DR jPOST; P04440; -.
DR MassIVE; P04440; -.
DR MaxQB; P04440; -.
DR PaxDb; P04440; -.
DR PeptideAtlas; P04440; -.
DR PRIDE; P04440; -.
DR ProteomicsDB; 51715; -.
DR Antibodypedia; 28872; 584 antibodies from 37 providers.
DR CPTC; P04440; 2 antibodies.
DR DNASU; 3115; -.
DR Ensembl; ENST00000399500.6; ENSP00000382422.2; ENSG00000215048.13.
DR Ensembl; ENST00000411749.6; ENSP00000414196.2; ENSG00000236693.11.
DR Ensembl; ENST00000418931.7; ENSP00000408146.2; ENSG00000223865.11.
DR Ensembl; ENST00000425130.6; ENSP00000396095.2; ENSG00000230763.11.
DR Ensembl; ENST00000433800.6; ENSP00000407674.2; ENSG00000226826.10.
DR Ensembl; ENST00000454006.6; ENSP00000389288.2; ENSG00000237710.10.
DR GeneID; 3115; -.
DR KEGG; hsa:3115; -.
DR MANE-Select; ENST00000418931.7; ENSP00000408146.2; NM_002121.6; NP_002112.3.
DR UCSC; uc003ocu.3; human.
DR CTD; 3115; -.
DR DisGeNET; 3115; -.
DR GeneCards; HLA-DPB1; -.
DR HGNC; HGNC:4940; HLA-DPB1.
DR HPA; ENSG00000223865; Tissue enhanced (lung, lymphoid tissue).
DR MalaCards; HLA-DPB1; -.
DR MIM; 142858; gene.
DR neXtProt; NX_P04440; -.
DR OpenTargets; ENSG00000223865; -.
DR Orphanet; 133; Chronic beryllium disease.
DR Orphanet; 900; Granulomatosis with polyangiitis.
DR PharmGKB; PA35064; -.
DR VEuPathDB; HostDB:ENSG00000223865; -.
DR eggNOG; ENOG502RYNI; Eukaryota.
DR GeneTree; ENSGT00940000162390; -.
DR InParanoid; P04440; -.
DR OMA; ICQVEHT; -.
DR OrthoDB; 1249505at2759; -.
DR PhylomeDB; P04440; -.
DR TreeFam; TF336626; -.
DR PathwayCommons; P04440; -.
DR Reactome; R-HSA-202424; Downstream TCR signaling.
DR Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-HSA-202433; Generation of second messenger molecules.
DR Reactome; R-HSA-2132295; MHC class II antigen presentation.
DR Reactome; R-HSA-389948; PD-1 signaling.
DR Reactome; R-HSA-877300; Interferon gamma signaling.
DR SignaLink; P04440; -.
DR SIGNOR; P04440; -.
DR BioGRID-ORCS; 3115; 13 hits in 1057 CRISPR screens.
DR ChiTaRS; HLA-DPB1; human.
DR EvolutionaryTrace; P04440; -.
DR GeneWiki; HLA-DPB1; -.
DR GenomeRNAi; 3115; -.
DR Pharos; P04440; Tbio.
DR PRO; PR:P04440; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P04440; protein.
DR Bgee; ENSG00000223865; Expressed in granulocyte and 104 other tissues.
DR ExpressionAtlas; P04440; baseline and differential.
DR Genevisible; P04440; HS.
DR GO; GO:0009986; C:cell surface; IMP:UniProtKB.
DR GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0042613; C:MHC class II protein complex; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
DR GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042605; F:peptide antigen binding; IDA:UniProtKB.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:UniProtKB.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IMP:UniProtKB.
DR GO; GO:0050870; P:positive regulation of T cell activation; IMP:UniProtKB.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Cell membrane; Disulfide bond;
KW Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Immunity;
KW Lysosome; Membrane; MHC II; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT CHAIN 30..258
FT /note="HLA class II histocompatibility antigen, DP beta 1
FT chain"
FT /id="PRO_0000018984"
FT TOPO_DOM 30..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 124..212
FT /note="Ig-like C1-type"
FT REGION 30..121
FT /note="Beta-1"
FT REGION 122..215
FT /note="Beta-2"
FT REGION 216..225
FT /note="Connecting peptide"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 144..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 16
FT /note="T -> M (in allele DPB1*09:02; dbSNP:rs41558014)"
FT /id="VAR_060627"
FT VARIANT 24
FT /note="T -> I (in dbSNP:rs11551416)"
FT /id="VAR_060628"
FT VARIANT 30
FT /note="R -> P (in allele DPB1*75:01)"
FT /id="VAR_060629"
FT VARIANT 31
FT /note="A -> L (in allele DPB1*75:01; requires 2 nucleotide
FT substitutions)"
FT /id="VAR_060630"
FT VARIANT 32
FT /note="T -> P (in allele DPB1*75:01)"
FT /id="VAR_060631"
FT VARIANT 33
FT /note="P -> A (in allele DPB1*75:01)"
FT /id="VAR_060632"
FT VARIANT 37
FT /note="L -> V (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01,
FT allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01,
FT allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01,
FT allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02,
FT allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01,
FT allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:02,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01,
FT allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01,
FT allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01,
FT allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01,
FT allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01,
FT allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01,
FT allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01,
FT allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01,
FT allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01,
FT allele DPB1*93:01 and allele DPB1*98:01; dbSNP:rs1126504)"
FT /id="VAR_060633"
FT VARIANT 38
FT /note="F -> D (in allele DPB1*70:01; requires 2 nucleotide
FT substitutions)"
FT /id="VAR_060635"
FT VARIANT 38
FT /note="F -> H (in allele DPB1*09:01, allele DPB1*10:01,
FT allele DPB1*14:01, allele DPB1*16:02, allele DPB1*17:01,
FT allele DPB1*22:02, allele DPB1*30:01, allele DPB1*35:01,
FT allele DPB1*45:01, allele DPB1*54:01, allele DPB1*55:01,
FT allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01,
FT allele DPB1*76:01, allele DPB1*86:01, allele DPB1*91:01 and
FT allele DPB1*98:01; requires 2 nucleotide substitutions)"
FT /id="VAR_060634"
FT VARIANT 38
FT /note="F -> L (in dbSNP:rs12722013)"
FT /id="VAR_060636"
FT VARIANT 38
FT /note="F -> Y (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:02,
FT allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01,
FT allele DPB1*13:02, allele DPB1*14:02, allele DPB1*15:01,
FT allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02,
FT allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*44:01, allele DPB1*50:01,
FT allele DPB1*52:01, allele DPB1*56:01, allele DPB1*69:01,
FT allele DPB1*74:01, allele DPB1*78:01, allele DPB1*79:01,
FT allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01,
FT allele DPB1*89:01, allele DPB1*90:01, allele DPB1*92:01 and
FT allele DPB1*93:01; dbSNP:rs1126509)"
FT /id="VAR_033433"
FT VARIANT 40
FT /note="G -> L (in allele DPB1*03:01, allele DPB1*05:02,
FT allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02,
FT allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02,
FT allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01,
FT allele DPB1*14:02, allele DPB1*16:02, allele DPB1*17:01,
FT allele DPB1*17:02, allele DPB1*20:02, allele DPB1*21:01,
FT allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01,
FT allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01,
FT allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01,
FT allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01,
FT allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01,
FT allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01,
FT allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01,
FT allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01,
FT allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01;
FT requires 2 nucleotide substitutions; dbSNP:rs386699869)"
FT /id="VAR_060637"
FT VARIANT 40
FT /note="G -> V (in dbSNP:rs1126513)"
FT /id="VAR_033434"
FT VARIANT 41
FT /note="R -> L (in allele DPB1*77:01; dbSNP:rs41540313)"
FT /id="VAR_060638"
FT VARIANT 44
FT /note="C -> G (in allele DPB1*26:02; dbSNP:rs1424116907)"
FT /id="VAR_060639"
FT VARIANT 46
FT /note="A -> P (in allele DPB1*38:01; dbSNP:rs41555313)"
FT /id="VAR_060640"
FT VARIANT 46
FT /note="A -> T (in allele DPB1*18:02; dbSNP:rs41555313)"
FT /id="VAR_060641"
FT VARIANT 57
FT /note="Y -> D (in allele DPB1*99:01; dbSNP:rs41553416)"
FT /id="VAR_060642"
FT VARIANT 61
FT /note="R -> P (in allele DPB1*14:02 and allele DPB1*21:02;
FT dbSNP:rs41561114)"
FT /id="VAR_060643"
FT VARIANT 62
FT /note="E -> Q (ind allele DPB1*11:01, allele DPB1*15:01 and
FT allele DPB1*74:01; dbSNP:rs12722018)"
FT /id="VAR_033435"
FT VARIANT 64
FT /note="F -> L (in allele DPB1*02:02, allele DPB1*02:03,
FT allele DPB1*05:01, allele DPB1*15:02, allele DPB1*17:02,
FT allele DPB1*19:02, allele DPB1*21:01, allele DPB1*21:01,
FT allele DPB1*22:01, allele DPB1*34:01, allele DPB1*36:01,
FT allele DPB1*38:01, allele DPB1*44:01, allele DPB1*48:01,
FT allele DPB1*58:01, allele DPB1*62:01, allele DPB1*63:01,
FT allele DPB1*95:01 and allele DPB1*97:01; dbSNP:rs9277348)"
FT /id="VAR_060644"
FT VARIANT 64
FT /note="F -> Y (in allele DPB1*01:01, allele DPB1*01:02,
FT allele DPB1*09:02, allele DPB1*11:01, allele DPB1*13:01,
FT allele DPB1*15:01, allele DPB1*20:02, allele DPB1*21:02,
FT allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01,
FT allele DPB1*39:01, allele DPB1*40:01, allele DPB1*49:01,
FT allele DPB1*53:01, allele DPB1*65:01, allele DPB1*74:01,
FT allele DPB1*85:01, allele DPB1*89:01 and allele DPB1*96:01;
FT dbSNP:rs1042117)"
FT /id="VAR_033436"
FT VARIANT 65
FT /note="A -> V (in allele DPB1*01:02, allele DPB1*02:01,
FT allele DPB1*02:02, allele DPB1*02:03, allele DPB1*03:01,
FT allele DPB1*04:02, allele DPB1*04:03, allele DPB1*05:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02,
FT allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01,
FT allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:02,
FT allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01,
FT allele DPB1*17:02, allele DPB1*18:01, allele DPB1*18:02,
FT allele DPB1*19:01, allele DPB1*19:02, allele DPB1*21:01,
FT allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02,
FT allele DPB1*23:01, allele DPB1*25:01, allele DPB1*26:02,
FT allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01,
FT allele DPB1*34:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*38:01, allele DPB1*41:01,
FT allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01,
FT allele DPB1*47:01, allele DPB1*48:01, allele DPB1*50:01,
FT allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01,
FT allele DPB1*57:01, allele DPB1*58:01, allele DPB1*59:01,
FT allele DPB1*60:01, allele DPB1*62:01, allele DPB1*63:01,
FT allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01,
FT allele DPB1*70:01, allele DPB1*71:01, allele DPB1*73:01,
FT allele DPB1*75:01, allele DPB1*77:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*80:01, allele DPB1*82:01,
FT allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01,
FT allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01,
FT allele DPB1*93:01, allele DPB1*94:01, allele DPB1*95:01,
FT allele DPB1*97:01 and allele DPB1*98:01; dbSNP:rs1042121)"
FT /id="VAR_033437"
FT VARIANT 68
FT /note="D -> Y (in allele DPB1*24:02; dbSNP:rs77062860)"
FT /id="VAR_060645"
FT VARIANT 72
FT /note="G -> W (in allele DPB1*97:01; dbSNP:rs41552915)"
FT /id="VAR_060646"
FT VARIANT 84
FT /note="A -> D (in allele DPB1*02:01, allele DPB1*03:01,
FT allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01,
FT allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01,
FT allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01,
FT allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01,
FT allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02,
FT allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01,
FT allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01,
FT allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01,
FT allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01,
FT allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01,
FT allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01,
FT allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01,
FT allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01,
FT allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01,
FT allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01,
FT allele DPB1*82:01, allele DPB1*83:01, allele DPB1*86:01,
FT allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01,
FT allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01;
FT dbSNP:rs707958)"
FT /id="VAR_054662"
FT VARIANT 84
FT /note="A -> E (in allele DPB1*01:02, allele DPB1*02:02,
FT allele DPB1*02:03, allele DPB1*05:01, allele DPB1*08:02,
FT allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01,
FT allele DPB1*22:01, allele DPB1*24:01, allele DPB1*30:01,
FT allele DPB1*36:01, allele DPB1*38:01, allele DPB1*47:01,
FT allele DPB1*54:01, allele DPB1*84:01 and allele DPB1*97:01;
FT dbSNP:rs386699870)"
FT /id="VAR_060647"
FT VARIANT 84
FT /note="A -> V (in dbSNP:rs707958)"
FT /id="VAR_059511"
FT VARIANT 85
FT /note="A -> E (in allele DPB1*02:01, allele DPB1*03:01,
FT allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01,
FT allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01,
FT allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01,
FT allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01,
FT allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01,
FT allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02,
FT allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01,
FT allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01,
FT allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01,
FT allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01,
FT allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01,
FT allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01,
FT allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01,
FT allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01,
FT allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01,
FT allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01,
FT allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01,
FT allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01,
FT allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01;
FT dbSNP:rs1042131)"
FT /id="VAR_033438"
FT VARIANT 86
FT /note="E -> D (in allele DPB1*03:01, allele DPB1*05:02,
FT allele DPB1*06:01, allele DPB1*09:01, allele DPB1*10:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:01,
FT allele DPB1*20:01, allele DPB1*22:02, allele DPB1*29:01,
FT allele DPB1*35:01, allele DPB1*44:01, allele DPB1*46:01,
FT allele DPB1*50:01, allele DPB1*57:01, allele DPB1*69:01,
FT allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*80:01, allele DPB1*86:01, allele DPB1*88:01,
FT allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*98:01;
FT dbSNP:rs1042133)"
FT /id="VAR_033439"
FT VARIANT 86
FT /note="E -> V (in allele DPB1*32:01; dbSNP:rs41545212)"
FT /id="VAR_060648"
FT VARIANT 89
FT /note="N -> H (in allele DPB1*02:03; dbSNP:rs41550319)"
FT /id="VAR_060649"
FT VARIANT 93
FT /note="D -> H (in allele DPB1*96:01; dbSNP:rs41560812)"
FT /id="VAR_060650"
FT VARIANT 94
FT /note="I -> F (allele DPB1*41:01 and allele DPB1*83:01;
FT dbSNP:rs1042136)"
FT /id="VAR_059512"
FT VARIANT 94
FT /note="I -> L (in allele DPB1*03:01, allele DPB1*03:02,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*10:02,
FT allele DPB1*11:01, allele DPB1*14:01, allele DPB1*14:02,
FT allele DPB1*15:01, allele DPB1*17:02, allele DPB1*20:01,
FT allele DPB1*22:02, allele DPB1*25:01, allele DPB1*28:01,
FT allele DPB1*29:01, allele DPB1*31:01, allele DPB1*34:01,
FT allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01,
FT allele DPB1*52:01, allele DPB1*56:01, allele DPB1*57:01,
FT allele DPB1*59:01, allele DPB1*67:01, allele DPB1*69:01,
FT allele DPB1*70:01, allele DPB1*72:01, allele DPB1*73:01,
FT allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*87:01, allele DPB1*91:01, allele DPB1*92:01 and
FT allele DPB1*95:01; dbSNP:rs1042136)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_059513"
FT VARIANT 94
FT /note="I -> N (in allele DPB1*60:01; dbSNP:rs41547212)"
FT /id="VAR_060651"
FT VARIANT 98
FT /note="K -> E (in allele DPB1*02:01, allele DPB1*02:02,
FT allele DPB1*02:03, allele DPB1*04:03, allele DPB1*06:01,
FT allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01,
FT allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:02,
FT allele DPB1*13:01, allele DPB1*13:02, allele DPB1*16:01,
FT allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:02,
FT allele DPB1*19:01, allele DPB1*20:02, allele DPB1*21:01,
FT allele DPB1*22:01, allele DPB1*26:02, allele DPB1*29:01,
FT allele DPB1*30:01, allele DPB1*32:01, allele DPB1*33:01,
FT allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01,
FT allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01,
FT allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01,
FT allele DPB1*71:01, allele DPB1*81:01, allele DPB1*86:01,
FT allele DPB1*88:01, allele DPB1*93:01 and allele DPB1*95:01;
FT dbSNP:rs1042140)"
FT /id="VAR_033440"
FT VARIANT 98
FT /note="K -> R (in allele DPB1*11:01, allele DPB1*15:01,
FT allele DPB1*69:01 and allele DPB1*74:01; dbSNP:rs12722027)"
FT /id="VAR_033441"
FT VARIANT 99
FT /note="R -> W (in allele DPB1*94:01; dbSNP:rs41554314)"
FT /id="VAR_060652"
FT VARIANT 101
FT /note="V -> L (in allele DPB1*31:01 and allele DPB1*34:01;
FT dbSNP:rs41546618)"
FT /id="VAR_060653"
FT VARIANT 102
FT /note="P -> L (in allele DPB1*78:01; dbSNP:rs41551920)"
FT /id="VAR_060654"
FT VARIANT 105
FT /note="M -> I (in allele DPB1*08:02, allele DPB1*09:02,
FT allele DPB1*13:01, allele DPB1*13:02 and allele DPB1*19:01;
FT dbSNP:rs1042153)"
FT /id="VAR_033443"
FT VARIANT 105
FT /note="M -> V (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*05:02, allele DPB1*08:01, allele DPB1*09:01,
FT allele DPB1*10:01, allele DPB1*14:01, allele DPB1*14:02,
FT allele DPB1*17:02, allele DPB1*21:02, allele DPB1*22:02,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*29:01, allele DPB1*35:01, allele DPB1*37:01,
FT allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01,
FT allele DPB1*52:01, allele DPB1*54:01, allele DPB1*56:01,
FT allele DPB1*57:01, allele DPB1*65:01, allele DPB1*67:01,
FT allele DPB1*68:01, allele DPB1*70:01, allele DPB1*73:01,
FT allele DPB1*75:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*84:01, allele DPB1*88:01,
FT allele DPB1*90:01 and allele DPB1*92:01; dbSNP:rs1042151)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_033442"
FT VARIANT 113
FT /note="G -> D (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01,
FT allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02,
FT allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:01,
FT allele DPB1*13:01, allele DPB1*13:02, allele DPB1*13:02,
FT allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01,
FT allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01,
FT allele DPB1*21:01, allele DPB1*21:01, allele DPB1*21:02,
FT allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01,
FT allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01,
FT allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01,
FT allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01,
FT allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01,
FT allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01,
FT allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01,
FT allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01,
FT allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01,
FT allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01,
FT allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and
FT allele DPB1*98:01; dbSNP:rs1042169)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_060657"
FT VARIANT 113
FT /note="G -> N (in allele DPB1*22:02; requires 2 nucleotide
FT substitutions)"
FT /id="VAR_060655"
FT VARIANT 113
FT /note="G -> V (in allele DPB1*15:01, allele DPB1*18:01,
FT allele DPB1*28:01, allele DPB1*34:01, allele DPB1*40:01,
FT allele DPB1*53:01, allele DPB1*62:01 and allele DPB1*74:01;
FT dbSNP:rs1042169)"
FT /id="VAR_060656"
FT VARIANT 114
FT /note="G -> E (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01,
FT allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02,
FT allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01,
FT allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02,
FT allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02,
FT allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02,
FT allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01,
FT allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01,
FT allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01,
FT allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01,
FT allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01,
FT allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01,
FT allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01,
FT allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01,
FT allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01,
FT allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01,
FT allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and
FT allele DPB1*98:01; dbSNP:rs9277354)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_033444"
FT VARIANT 115
FT /note="P -> A (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01,
FT allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02,
FT allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01,
FT allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02,
FT allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02,
FT allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02,
FT allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01,
FT allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01,
FT allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01,
FT allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01,
FT allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01,
FT allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01,
FT allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01,
FT allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01,
FT allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01,
FT allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01,
FT allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and
FT allele DPB1*98:01; dbSNP:rs9277355)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_033445"
FT VARIANT 116
FT /note="M -> V (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01,
FT allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01,
FT allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02,
FT allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01,
FT allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02,
FT allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02,
FT allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02,
FT allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02,
FT allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01,
FT allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01,
FT allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01,
FT allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01,
FT allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01,
FT allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01,
FT allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01,
FT allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01,
FT allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01,
FT allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01,
FT allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01,
FT allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01,
FT allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01;
FT dbSNP:rs9277356)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_033446"
FT VARIANT 120
FT /note="R -> H (in allele DPB1*82:01 and allele DPB1*85:01;
FT dbSNP:rs41541915)"
FT /id="VAR_060658"
FT VARIANT 125
FT /note="R -> K (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01,
FT allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01,
FT allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01,
FT allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01,
FT allele DPB1*45:01 and allele DPB1*85:01; dbSNP:rs1126537)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_060659"
FT VARIANT 199
FT /note="T -> I (in allele DPB1*01:01, allele DPB1*03:01,
FT allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01,
FT allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01,
FT allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01,
FT allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01,
FT allele DPB1*45:01 and allele DPB1*85:01; dbSNP:rs1042335)"
FT /evidence="ECO:0000269|PubMed:6330724"
FT /id="VAR_060660"
FT VARIANT 207
FT /note="L -> M (in allele DPB1*04:02; dbSNP:rs14362)"
FT /id="VAR_033447"
FT VARIANT 223
FT /note="R -> Q (in allele DPB1*01:01; dbSNP:rs9276)"
FT /id="VAR_050393"
FT VARIANT 234
FT /note="V -> M (in allele DPB1*05:01 and allele DPB1*19:01;
FT dbSNP:rs11551421)"
FT /id="VAR_050394"
FT VARIANT 244
FT /note="I -> T (in allele DPB1*15:01; dbSNP:rs3097675)"
FT /id="VAR_033448"
FT STRAND 37..47
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 50..59
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 62..68
FT /evidence="ECO:0007829|PDB:4P5M"
FT TURN 69..71
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 73..78
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 82..89
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 92..99
FT /evidence="ECO:0007829|PDB:4P5M"
FT TURN 100..104
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 105..112
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 114..118
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:4P5M"
FT HELIX 134..137
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 141..152
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 155..160
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 163..165
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 167..171
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 178..180
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 182..189
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 197..203
FT /evidence="ECO:0007829|PDB:4P5M"
FT STRAND 211..216
FT /evidence="ECO:0007829|PDB:4P5M"
SQ SEQUENCE 258 AA; 29159 MW; E74777D438DE9C41 CRC64;
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN
REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRMCRHNY ELGGPMTLQR
RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW
TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC
GVGIFMHRRS KKVQRGSA
