ID   DPB2_CANGA              Reviewed;         719 AA.
AC   Q6FSK8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=CAGL0G09801g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; CR380953; CAG59713.1; -; Genomic_DNA.
DR   RefSeq; XP_446786.1; XM_446786.1.
DR   AlphaFoldDB; Q6FSK8; -.
DR   SMR; Q6FSK8; -.
DR   STRING; 5478.XP_446786.1; -.
DR   PRIDE; Q6FSK8; -.
DR   EnsemblFungi; CAG59713; CAG59713; CAGL0G09801g.
DR   GeneID; 2888291; -.
DR   KEGG; cgr:CAGL0G09801g; -.
DR   CGD; CAL0137567; CAGL0G09801g.
DR   VEuPathDB; FungiDB:CAGL0G09801g; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; Q6FSK8; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0043596; C:nuclear replication fork; IEA:EnsemblFungi.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:EnsemblFungi.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0045005; P:DNA-templated DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IEA:EnsemblFungi.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..719
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071567"
FT   REGION          107..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  81472 MW;  89EC061E3976F157 CRC64;
     MFTSGKVLPT KIQPPLLRPM AYRVLSKKYG LSIKSDGLAA LSDFIGSTFG MDWKRNPDTI
     KFLEVFATVW KQQERGLFVD STGVKDVINE LKEREKATLQ ESQNMASIPP KTKTYNNGGG
     KTTTIDRFLT KRPSPSDNDE GPLDQSIDDI PVSQATQIDE EELPMAQEIS DQISSPARDQ
     TPEEEFDNRI LNWRDYFRII NTTDQKKFSY NPVKRQIFYQ PPKDQLKSVL KIPNAQAKTD
     LFRTRYFLTR DRLLRNESFQ SSHDTFNPLS SMIQLKNNIN NNNQDDTPTG LSITQIKNLL
     GRDGQNFLIL GVLKMNPKGQ WSLEDASGSI DIDISQTLPS PGLFYIPGAI VLAEGIYYTV
     GHTFAVTSMT FPPGERRDKT LDHIGNLDLL GIHGTEKSSY IPRLDNEIKI RLHLLEQDLT
     HQKFVLLGGD LFLDDQHVMD GLKKVFTKLD QEAPTVIVLF GSFSSFPVHA AMSSKNISST
     TEYKNNFDSL AEMLSQFENI INHTHVVLIP GPHDPWVSLC SLGANGSLPQ SSIPTHFSKR
     MNKICKNITW ASNPTRIAYL SQEIVLFRDN FLELCKRHQI LFPVVESKRA EDLAELEEQM
     ANNSIDDTTI LVDRIISEKQ QLPAKVLESR KVVKTLLDQG HLSPFVDSIR PISWDMDHTL
     TLYPIPSTLI LADMSSAAYD LTYNGCKTIN PGKFIHKRQA RYIQFQPYLK SVSQEEVFF