ID   DPB2_CRYNJ              Reviewed;         541 AA.
AC   P0CN24; Q55R91; Q5KEX9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=CNF03830;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; AE017346; AAW44369.1; -; Genomic_DNA.
DR   RefSeq; XP_571676.1; XM_571676.1.
DR   AlphaFoldDB; P0CN24; -.
DR   SMR; P0CN24; -.
DR   STRING; 5207.AAW44369; -.
DR   PaxDb; P0CN24; -.
DR   EnsemblFungi; AAW44369; AAW44369; CNF03830.
DR   GeneID; 3258219; -.
DR   KEGG; cne:CNF03830; -.
DR   VEuPathDB; FungiDB:CNF03830; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_2_1_1; -.
DR   InParanoid; P0CN24; -.
DR   OMA; CRLQYCT; -.
DR   OrthoDB; 375960at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140529; P:CMG complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   GO; GO:1902975; P:mitotic DNA replication initiation; IEA:EnsemblFungi.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..541
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071568"
SQ   SEQUENCE   541 AA;  61072 MW;  464FE1F1AF34F662 CRC64;
     MVNQMRSAIV KVFSTKHSLT LPAPALHYIE EVLIENEIPE DEWMVGLEFW AKEYLKAEDS
     SSLVSLQALK KAYENLQLGT TEDTQVADPS EVNVESHFSV VDSFDMPAMR YDPVRSGFVQ
     SKAQPSVAGQ ASSRSAFLRE RWAIIKEIIL RNENFTPPAI GGHDRANYLK LTSIRNLLGR
     AGQLFLLFGM LARNEEGKLC LEDGESRVVL DMEDAVPGEG LFTEGCMVLI EGEYTVEETV
     RVLAMGHPPS ERRNIARSLH GHVDFLGGGA VSLKEEQKYN PTVLANTQIS FVILSDVWLD
     HPRTMPALRQ MFEGYANTAE YRPMVFVLCG NFCQGGWEGQ EGLKRYSRGF NSLAELLQSI
     PLLHSSHFVF VPGPSDPWSS TTLPRPSLPS AFTTRLSNRI PNARFVSNPC RLKYFGMEIV
     ICREDLMGKM MRNLVVVKEG EEMNMKRYLV QTILDQAHLS PLPISVRPTL WEYDHALRLY
     PMPSAVVLAD KYERYELTYE GCHVFNPGKF VGGIGEDGWE FEWSMYYPAT GRSERSVLTM
     E