ID   ADEC1_RHIL3             Reviewed;         569 AA.
AC   Q1MDE8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Adenine deaminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 1 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade1 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=RL3541;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA   Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA   East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA   Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT   components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AM236080; CAK09029.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1MDE8; -.
DR   SMR; Q1MDE8; -.
DR   STRING; 216596.RL3541; -.
DR   EnsemblBacteria; CAK09029; CAK09029; RL3541.
DR   KEGG; rle:RL3541; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese.
FT   CHAIN           1..569
FT                   /note="Adenine deaminase 1"
FT                   /id="PRO_0000292394"
SQ   SEQUENCE   569 AA;  61076 MW;  7078051D6BA25993 CRC64;
     MSNAMTSKLE RFIDQGVGRV PADIVLKGGC FFDLVTGELV QSDIAIGADR IVGTSGNYEG
     ETEIDISGRI VVPGFIDTHL HIESSLVTPH EFDRCVLPYG VTTAICDPHE IANVLGAAGI
     EFFLESALET IMDIRVQLSS CVPATHLETS GADLPIESLL PYRHHPKVIG LAEFMNFPGV
     IHKDPICMAK LDAFQGGHID GHAPLLSGND LNGYLAAGIR TEHECTTASE ALEKIRKGVH
     ILVREGSVSK DLAALMPIIT ERLSPFLALC TDDRNPLDIA EQGHLDHMIR TAIASRVEPL
     AIYRAASISA ARAFGLKDRG LVAPGWRADL VVLDSLENCR ADMVFSAGRR VTDALFSSRR
     PVAPIGLDSV KARPVNAAHF GVPVAEGETP VIGVIPGKII TEHRRYRLPV RGNEAAVDLA
     NDIIKVAVIE RHGKNGNHAN GFVQGFGLKK GAIASTVGHD SHNICVVGVS EDDMARAANR
     LSEIKGGFVV VEDGKVTGEI ALPIAGLMSL EPYETVRDTL HQLRKAAFAL GATLEEPFLQ
     LAFLPLPVIP HLKISDRGMV DVDKFALIG