ID   DPB2_DEBHA              Reviewed;         669 AA.
AC   Q6BQR8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=DEHA2E02838g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; CR382137; CAG87668.1; -; Genomic_DNA.
DR   RefSeq; XP_459452.1; XM_459452.1.
DR   AlphaFoldDB; Q6BQR8; -.
DR   SMR; Q6BQR8; -.
DR   STRING; 4959.XP_459452.1; -.
DR   EnsemblFungi; CAG87668; CAG87668; DEHA2E02838g.
DR   GeneID; 2902070; -.
DR   KEGG; dha:DEHA2E02838g; -.
DR   VEuPathDB; FungiDB:DEHA2E02838g; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; Q6BQR8; -.
DR   OMA; GWVDFLG; -.
DR   OrthoDB; 375960at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..669
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071569"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  75781 MW;  3F9D12B772E97CE1 CRC64;
     MENPSALPIK LQPSNLRPIA YRILSKKHGL NIQTDALKLL TDAVSYKFGF DWKSTQSQQF
     LEEIAKIWKK QDRGIFIDGP GLKQVIKELS DRNTNQISTR NGSADNLAKK AERSDTLVDN
     DAENEPVNNA ENTLNWQDYF KVINPDEQPN YKYDKHRKQL SFIPSTNAKR LANNLNSNVD
     YFNNRYHLIS DRLSRNENFQ KPSFSSISSI SKSLSHNNKT NEITLIKNVL GRDGSKFILF
     GLLSKNANDD FILEDSTDHI ELNLTQAYKT EGSFYCPGMF VIVEGIYSAS GGSMSNANVI
     GGCFHVSNIG HPPAERRELS MENYGNLDFM GINRDNDTNN NDNHILRVNK SLKKKLVSLE
     KTLVNHKLII LGSDCFLDDL KILDGIKKLF GKIESSLIDD ETNQPLVIVL IGSFTSNPLT
     PTNSSVANVS NTENYKSNFD NLSNILSNFP NIVQKVKIAL IPGINDPWQS SHSLGGSNLN
     AFPQRSIPKI FTNRLERLLP KGNLIAGWNP LRINYLSQEI VLMKDDIINK FKRNDIIFSN
     DLELEQLKLQ KDKNDDGLIH ATDINTKEPH ISPKIKQARK LVKTILDQGN LQPFLKDIRI
     INTNFDYSLR IEPLPTILIL NDATFPTFEV TYNGCKVINT GKLVGNNRKL SFVEYFPSGK
     KFEFKEVYF