ID   DPB2_KLULA              Reviewed;         710 AA.
AC   Q6CPH8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=KLLA0E04697g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; CR382125; CAG99248.1; -; Genomic_DNA.
DR   RefSeq; XP_454161.1; XM_454161.1.
DR   AlphaFoldDB; Q6CPH8; -.
DR   SMR; Q6CPH8; -.
DR   STRING; 28985.XP_454161.1; -.
DR   EnsemblFungi; CAG99248; CAG99248; KLLA0_E04775g.
DR   GeneID; 2893904; -.
DR   KEGG; kla:KLLA0_E04775g; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; Q6CPH8; -.
DR   OMA; GWVDFLG; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0043596; C:nuclear replication fork; IEA:EnsemblFungi.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:EnsemblFungi.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0045005; P:DNA-templated DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IEA:EnsemblFungi.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..710
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071570"
FT   REGION          116..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  80465 MW;  F127E3C87D67083B CRC64;
     MAGVVLPASI QPQLLRPLAY RILTKKFGLN IKSDGLVALA AYIGTVFGLY WRQNSETTKF
     LEQFAIIWRE QGRGLFVDEL NVSQVINEIK EREKIEQDQH VEKRNNLHKA NNLDAFLKRP
     NSPTDTEITT LSQGSATSVV NPDSHSPMML EEGSPINSDS EPISEHERAN GISNVDQQLD
     WLDYFKVIDA FNQQTFTYDH TKRQYIYVPR PKEVEKNMLS IAKLKLPNVE SKVSLFTTRY
     HIIKDKVLRN EKFQNNDIFN PLSSIIEMGK HMNESDVSPL NSASYMKITQ IKNLLGHDGK
     NFLLLGLLDQ NSKGNWSLED PSGSIELHLQ QAIPTKGTYY VPGCIVLVEG IYYTASNTFV
     VSSITHPPGE KREDTIEAIG NLDLLGAYNP SNENYVARLD KDLKIRLHYL EQELSDNKFV
     ILGGDIYLDE MTTMDGLKKT FDKLTTDPPV AIVFNGSFVS VPVHPSLNAK NVSATVSYKN
     NFDALATLLS NYENLINDTH MIFIPGPNDP WTSMVGLGTT TMWPQKIIPS SFTQKMSRIC
     RKVHWGSNPL RIAYLSQEIV LTRDDLANRF KRYNIVFPTV EEEKYLENAE LQEQYSRNPD
     VSVGQLIAFK NNLPVSVLES RKLVKTLLDQ QHLSPFSSRI RPTVWDLDFT LQLSPLPSSI
     MLCDTSAPAF DVTYNGCKTI NPGRFIHKRA AKYIEFFPAS KVLVEEELPF