ID   DPB2_YARLI              Reviewed;         652 AA.
AC   Q6C030;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA polymerase epsilon subunit B;
DE   AltName: Full=DNA polymerase II subunit 2;
GN   Name=DPB2; OrderedLocusNames=YALI0F28215g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P24482}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; CR382132; CAG78794.1; -; Genomic_DNA.
DR   RefSeq; XP_505982.1; XM_505982.1.
DR   AlphaFoldDB; Q6C030; -.
DR   SMR; Q6C030; -.
DR   STRING; 4952.CAG78794; -.
DR   EnsemblFungi; CAG78794; CAG78794; YALI0_F28215g.
DR   GeneID; 2908660; -.
DR   KEGG; yli:YALI0F28215g; -.
DR   VEuPathDB; FungiDB:YALI0_F28215g; -.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; Q6C030; -.
DR   OMA; GWVDFLG; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0043596; C:nuclear replication fork; IEA:EnsemblFungi.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:EnsemblFungi.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0045005; P:DNA-templated DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..652
FT                   /note="DNA polymerase epsilon subunit B"
FT                   /id="PRO_0000071572"
SQ   SEQUENCE   652 AA;  73919 MW;  A8BA64532C7CCF9D CRC64;
     MPAVLPIKLN PSQMRPVAYR IFSKKHGLNL KSTGLETLTE IIGKNYGTEW RGAEAAKMME
     EICRLWKEQE MGVFVEGKPL QELFDEITAS KKAKEKARVQ VVSKSVGLTG VEEIEDREGE
     PQVNVIREAA PSVDVVWKEF FKVISAFDQP LFHYNARQQR FEKRKTKPTL FANAQSASNM
     FLTRYHLVYN RLLRNDDTTD LKITSIRSLI GRQGEFSIFG MLSKNPEQKI CLQDDTGRIL
     LILAAGCKPD PGVYYPEGSF VICNGRYMKS GDAEVFVVIT MGPPVAEKRQ ETITAYGNMD
     YLGLHGNPHG SVVRRIERQV EASMLAEEKR LVDQKVIVFG GDMYLDNPLT LKALQKVFST
     IELEFQDSGT KKPLAMVFSG DFTSQYQPPH LYKKGFDKLE ELFKEFSSII TGVKIIFVPG
     QRDPWTNTFP TQNAVVPLQP LPTTMINRVA RLCGEDVSMS SNPCRMAYLT QDMVFYRDGL
     SERLRKCNLQ LDSAKDDSDD SDDDIEIDND EVMINDVVVN EPESSFDFGE GLSNLTRPVD
     ISTPMASQVG PTNTLSAKEV ESRKIVRTIC DQGHLSPFNR HDRPVAWDYD ETLWLSPLPT
     ILFMVDTHAP KFSLRYEECM VVNPGPFLNR KIASWVEYDP SKKTVKERQL HI