ID   DPB3_KLULA              Reviewed;         166 AA.
AC   Q6CLM5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=DNA polymerase epsilon subunit C;
DE   AltName: Full=DNA polymerase II subunit C;
GN   Name=DPB3; OrderedLocusNames=KLLA0F01859g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: As accessory component of the DNA polymerase epsilon (DNA
CC       polymerase II) participates in chromosomal DNA replication.
CC       {ECO:0000250|UniProtKB:P27344}.
CC   -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3
CC       and DPB4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
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DR   EMBL; CR382126; CAG97871.1; -; Genomic_DNA.
DR   RefSeq; XP_455164.1; XM_455164.1.
DR   AlphaFoldDB; Q6CLM5; -.
DR   SMR; Q6CLM5; -.
DR   STRING; 28985.XP_455164.1; -.
DR   PRIDE; Q6CLM5; -.
DR   EnsemblFungi; CAG97871; CAG97871; KLLA0_F01859g.
DR   GeneID; 2895286; -.
DR   KEGG; kla:KLLA0_F01859g; -.
DR   eggNOG; KOG1658; Eukaryota.
DR   HOGENOM; CLU_086758_0_0_1; -.
DR   InParanoid; Q6CLM5; -.
DR   OMA; CKKIART; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..166
FT                   /note="DNA polymerase epsilon subunit C"
FT                   /id="PRO_0000208347"
FT   REGION          112..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   166 AA;  18703 MW;  9DABA971E41BA9FE CRC64;
     MDEYKSKLPR IPISKCKKIA RTDPEYILTS QAAFAATAFT TELFIQMLAE ETCSLAQIHK
     QTKTLRLNYE DLSTAIRNLD KFQFLSDVVP QTENLASLVR ENKVRYTIVN PSPEIDIESE
     DEVDEANEPE VGEPEVDEAE VEAEVEAEAA EPETHTLDEP RPESSS