DPCA2_HUMAN
ID DPCA2_HUMAN Reviewed; 172 AA.
AC Q86SG4; Q495B5; Q86SH8; Q8N8I5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Putative Dresden prostate carcinoma protein 2;
DE Short=D-PCa-2;
DE AltName: Full=High mobility group nucleosome-binding domain-containing protein 2 pseudogene 46;
GN Name=HMGN2P46; Synonyms=C15orf21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), AND TISSUE SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=15027122; DOI=10.1002/ijc.20049;
RA Weigle B., Kiessling A., Ebner R., Fuessel S., Temme A., Meye A.,
RA Schmitz M., Rieger M.A., Ockert D., Wirth M.P., Rieber E.P.;
RT "D-PCa-2: a novel transcript highly overexpressed in human prostate and
RT prostate cancer.";
RL Int. J. Cancer 109:882-892(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86SG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86SG4-2; Sequence=VSP_014625;
CC Name=3;
CC IsoId=Q86SG4-3; Sequence=VSP_014624;
CC -!- TISSUE SPECIFICITY: Very high expression in prostate and prostate
CC cancer. Faint expression in other tissues.
CC {ECO:0000269|PubMed:15027122}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AY271964; AAP12643.1; -; mRNA.
DR EMBL; AY271965; AAP12644.1; -; mRNA.
DR EMBL; AY271966; AAP12645.1; -; mRNA.
DR EMBL; AY271967; AAP12646.1; -; mRNA.
DR EMBL; AK096745; BAC04856.1; -; mRNA.
DR EMBL; AC025580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q86SG4; -.
DR IntAct; Q86SG4; 4.
DR MINT; Q86SG4; -.
DR BioMuta; HGNC:26817; -.
DR PRIDE; Q86SG4; -.
DR GeneCards; HMGN2P46; -.
DR HGNC; HGNC:26817; HMGN2P46.
DR MIM; 611314; gene.
DR neXtProt; NX_Q86SG4; -.
DR InParanoid; Q86SG4; -.
DR PhylomeDB; Q86SG4; -.
DR PathwayCommons; Q86SG4; -.
DR ChiTaRS; HMGN2P46; human.
DR Pharos; Q86SG4; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q86SG4; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..172
FT /note="Putative Dresden prostate carcinoma protein 2"
FT /id="PRO_0000079990"
FT REGION 40..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15027122"
FT /id="VSP_014624"
FT VAR_SEQ 1..12
FT /note="MEPWAMRALDFA -> MKE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014625"
FT VARIANT 91
FT /note="C -> R (in dbSNP:rs8042811)"
FT /id="VAR_022865"
SQ SEQUENCE 172 AA; 20403 MW; A4BF71B87716B156 CRC64;
MEPWAMRALD FADESGSVSC KDMHLLLWLQ KRIEMHKAEQ CEEEEAMTPR PTKARAPLPS
AYVPPLSLPP CPRERLKGML KEIKPRLSRN CREDPQGCLL NLLLQSHSRS PERPLQRRER
RYLQRRREKL MLARRGITLQ KMEMPKQTRH RKLKVLEMPS EVCAFLITVY FW
