DPCD_HUMAN
ID DPCD_HUMAN Reviewed; 203 AA.
AC Q9BVM2; A8K289; Q6QNL3; Q8N5R1; Q9UFY6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein DPCD;
GN Name=DPCD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-156.
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-203, FUNCTION, TISSUE SPECIFICITY, AND
RP VARIANTS ARG-56 AND SER-156.
RX PubMed=14630615; DOI=10.1165/rcmb.2003-0338rc;
RA Zariwala M., O'Neal W.K., Noone P.G., Leigh M.W., Knowles M.R.,
RA Ostrowski L.E.;
RT "Investigation of the possible role of a novel gene, DPCD, in primary
RT ciliary dyskinesia.";
RL Am. J. Respir. Cell Mol. Biol. 30:428-434(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-203, AND VARIANT SER-156.
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May play a role in the formation or function of ciliated
CC cells. {ECO:0000269|PubMed:14630615}.
CC -!- INTERACTION:
CC Q9BVM2; Q9Y230: RUVBL2; NbExp=10; IntAct=EBI-749988, EBI-352939;
CC -!- TISSUE SPECIFICITY: Highly expressed in the testis. Weakly expressed in
CC pancreas, skeletal muscle and heart. Expression increases during
CC ciliated cell differentiation. {ECO:0000269|PubMed:14630615}.
CC -!- SIMILARITY: Belongs to the DPCD family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK290154; BAF82843.1; -; mRNA.
DR EMBL; AL627424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001082; AAH01082.2; -; mRNA.
DR EMBL; BC031695; AAH31695.1; -; mRNA.
DR EMBL; AY532267; AAS46252.1; -; mRNA.
DR EMBL; AL110240; CAB53691.2; -; mRNA.
DR CCDS; CCDS7514.1; -.
DR PIR; T14771; T14771.
DR RefSeq; NP_056263.1; NM_015448.2.
DR AlphaFoldDB; Q9BVM2; -.
DR BioGRID; 117415; 47.
DR IntAct; Q9BVM2; 12.
DR STRING; 9606.ENSP00000359170; -.
DR GlyGen; Q9BVM2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BVM2; -.
DR PhosphoSitePlus; Q9BVM2; -.
DR BioMuta; DPCD; -.
DR EPD; Q9BVM2; -.
DR jPOST; Q9BVM2; -.
DR MassIVE; Q9BVM2; -.
DR MaxQB; Q9BVM2; -.
DR PaxDb; Q9BVM2; -.
DR PeptideAtlas; Q9BVM2; -.
DR PRIDE; Q9BVM2; -.
DR ProteomicsDB; 79219; -.
DR Antibodypedia; 31286; 185 antibodies from 23 providers.
DR DNASU; 25911; -.
DR Ensembl; ENST00000370151.9; ENSP00000359170.4; ENSG00000166171.13.
DR GeneID; 25911; -.
DR KEGG; hsa:25911; -.
DR MANE-Select; ENST00000370151.9; ENSP00000359170.4; NM_015448.3; NP_056263.1.
DR UCSC; uc001ktn.4; human.
DR CTD; 25911; -.
DR DisGeNET; 25911; -.
DR GeneCards; DPCD; -.
DR HGNC; HGNC:24542; DPCD.
DR HPA; ENSG00000166171; Tissue enhanced (testis).
DR MIM; 616467; gene.
DR neXtProt; NX_Q9BVM2; -.
DR OpenTargets; ENSG00000166171; -.
DR PharmGKB; PA165548502; -.
DR VEuPathDB; HostDB:ENSG00000166171; -.
DR eggNOG; ENOG502QUNA; Eukaryota.
DR GeneTree; ENSGT00390000014031; -.
DR HOGENOM; CLU_097313_0_0_1; -.
DR InParanoid; Q9BVM2; -.
DR OMA; IEWRIRN; -.
DR OrthoDB; 1352989at2759; -.
DR PhylomeDB; Q9BVM2; -.
DR TreeFam; TF324098; -.
DR PathwayCommons; Q9BVM2; -.
DR SignaLink; Q9BVM2; -.
DR BioGRID-ORCS; 25911; 49 hits in 1072 CRISPR screens.
DR ChiTaRS; DPCD; human.
DR GenomeRNAi; 25911; -.
DR Pharos; Q9BVM2; Tbio.
DR PRO; PR:Q9BVM2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9BVM2; protein.
DR Bgee; ENSG00000166171; Expressed in left testis and 177 other tissues.
DR ExpressionAtlas; Q9BVM2; baseline and differential.
DR Genevisible; Q9BVM2; HS.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0021670; P:lateral ventricle development; IEA:Ensembl.
DR GO; GO:0060972; P:left/right pattern formation; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0021678; P:third ventricle development; IEA:Ensembl.
DR InterPro; IPR026224; DPCD.
DR PANTHER; PTHR31921; PTHR31921; 1.
DR Pfam; PF14913; DPCD; 1.
DR PRINTS; PR02065; PROTEINDPCD.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..203
FT /note="Protein DPCD"
FT /id="PRO_0000323723"
FT VARIANT 56
FT /note="S -> R (in dbSNP:rs1331419018)"
FT /evidence="ECO:0000269|PubMed:14630615"
FT /id="VAR_039574"
FT VARIANT 156
FT /note="L -> S (in dbSNP:rs7006)"
FT /evidence="ECO:0000269|PubMed:14630615,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:17974005"
FT /id="VAR_039575"
FT CONFLICT 100
FT /note="M -> K (in Ref. 5; CAB53691)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 203 AA; 23240 MW; 2FBEDDA99F975760 CRC64;
MAVTGWLESL RTAQKTALLQ DGRRKVHYLF PDGKEMAEEY DEKTSELLVR KWRVKSALGA
MGQWQLEVGD PAPLGAGNLG PELIKESNAN PIFMRKDTKM SFQWRIRNLP YPKDVYSVSV
DQKERCIIVR TTNKKYYKKF SIPDLDRHQL PLDDALLSFA HANCTLIISY QKPKEVVVAE
SELQKELKKV KTAHSNDGDC KTQ
