DPCD_MOUSE
ID DPCD_MOUSE Reviewed; 203 AA.
AC Q8BPA8; Q8K1L8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein DPCD;
GN Name=Dpcd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the formation or function of ciliated
CC cells. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8BPA8; Q9Y230: RUVBL2; Xeno; NbExp=2; IntAct=EBI-26898155, EBI-352939;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BPA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BPA8-2; Sequence=VSP_032081, VSP_032082;
CC -!- SIMILARITY: Belongs to the DPCD family. {ECO:0000305}.
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DR EMBL; AK077347; BAC36762.1; -; mRNA.
DR EMBL; BC027559; AAH27559.1; -; mRNA.
DR CCDS; CCDS29862.1; -. [Q8BPA8-1]
DR RefSeq; NP_766227.1; NM_172639.2. [Q8BPA8-1]
DR AlphaFoldDB; Q8BPA8; -.
DR BioGRID; 230484; 10.
DR IntAct; Q8BPA8; 3.
DR MINT; Q8BPA8; -.
DR STRING; 10090.ENSMUSP00000045683; -.
DR PhosphoSitePlus; Q8BPA8; -.
DR EPD; Q8BPA8; -.
DR MaxQB; Q8BPA8; -.
DR PaxDb; Q8BPA8; -.
DR PeptideAtlas; Q8BPA8; -.
DR PRIDE; Q8BPA8; -.
DR ProteomicsDB; 279762; -. [Q8BPA8-1]
DR ProteomicsDB; 279763; -. [Q8BPA8-2]
DR Antibodypedia; 31286; 185 antibodies from 23 providers.
DR DNASU; 226162; -.
DR Ensembl; ENSMUST00000047057; ENSMUSP00000045683; ENSMUSG00000041035. [Q8BPA8-1]
DR GeneID; 226162; -.
DR KEGG; mmu:226162; -.
DR UCSC; uc008hrd.1; mouse. [Q8BPA8-1]
DR CTD; 25911; -.
DR MGI; MGI:1924407; Dpcd.
DR VEuPathDB; HostDB:ENSMUSG00000041035; -.
DR eggNOG; ENOG502QUNA; Eukaryota.
DR GeneTree; ENSGT00390000014031; -.
DR HOGENOM; CLU_097313_0_0_1; -.
DR InParanoid; Q8BPA8; -.
DR OMA; IEWRIRN; -.
DR OrthoDB; 1352989at2759; -.
DR PhylomeDB; Q8BPA8; -.
DR TreeFam; TF324098; -.
DR BioGRID-ORCS; 226162; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Dpcd; mouse.
DR PRO; PR:Q8BPA8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BPA8; protein.
DR Bgee; ENSMUSG00000041035; Expressed in choroid plexus epithelium and 262 other tissues.
DR ExpressionAtlas; Q8BPA8; baseline and differential.
DR Genevisible; Q8BPA8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IMP:MGI.
DR GO; GO:0051649; P:establishment of localization in cell; IMP:MGI.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR GO; GO:0021670; P:lateral ventricle development; IMP:MGI.
DR GO; GO:0060972; P:left/right pattern formation; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0021678; P:third ventricle development; IMP:MGI.
DR GO; GO:0021591; P:ventricular system development; IMP:MGI.
DR InterPro; IPR026224; DPCD.
DR PANTHER; PTHR31921; PTHR31921; 1.
DR Pfam; PF14913; DPCD; 1.
DR PRINTS; PR02065; PROTEINDPCD.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..203
FT /note="Protein DPCD"
FT /id="PRO_0000323724"
FT VAR_SEQ 87..112
FT /note="SNANPIFMRKDTKTSFQWRIRNLPYP -> THLHAQGHQNKFPVADSKSPLP
FT EGCV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032081"
FT VAR_SEQ 113..203
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032082"
SQ SEQUENCE 203 AA; 23034 MW; 73D41DFEA38EEA27 CRC64;
MAVTSWLEVL RSAEKTALLQ DGKRMVHYLF PDGKEMAEEY DEKTSELLVR KWRVKNALGA
LGQWQLEVGE PVPSGAGSLG SELIKESNAN PIFMRKDTKT SFQWRIRNLP YPKDVYSVSV
AQKERCVIVR TTNKKYYKKF SIPDLDRHQL PLEDSALSFA HANCTLIISY QKPKEVMAAE
SELQKELKKV KTAHGSAGDC KTQ
