DPCD_RAT
ID DPCD_RAT Reviewed; 203 AA.
AC Q6AYM4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein DPCD;
GN Name=Dpcd;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the formation or function of ciliated
CC cells. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6AYM4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6AYM4-2; Sequence=VSP_032083;
CC -!- SIMILARITY: Belongs to the DPCD family. {ECO:0000305}.
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DR EMBL; AABR03000057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03007566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03011265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03004155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC078988; AAH78988.1; -; mRNA.
DR RefSeq; NP_001013927.1; NM_001013905.1. [Q6AYM4-2]
DR RefSeq; XP_006231512.1; XM_006231450.3. [Q6AYM4-1]
DR AlphaFoldDB; Q6AYM4; -.
DR STRING; 10116.ENSRNOP00000023278; -.
DR PaxDb; Q6AYM4; -.
DR GeneID; 294004; -.
DR KEGG; rno:294004; -.
DR CTD; 25911; -.
DR RGD; 1307648; Dpcd.
DR VEuPathDB; HostDB:ENSRNOG00000017241; -.
DR eggNOG; ENOG502QUNA; Eukaryota.
DR HOGENOM; CLU_097313_0_0_1; -.
DR InParanoid; Q6AYM4; -.
DR OMA; IEWRIRN; -.
DR OrthoDB; 1352989at2759; -.
DR PhylomeDB; Q6AYM4; -.
DR TreeFam; TF324098; -.
DR PRO; PR:Q6AYM4; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000017241; Expressed in frontal cortex and 20 other tissues.
DR Genevisible; Q6AYM4; RN.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR GO; GO:0021670; P:lateral ventricle development; ISO:RGD.
DR GO; GO:0060972; P:left/right pattern formation; ISO:RGD.
DR GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR GO; GO:0021678; P:third ventricle development; ISO:RGD.
DR GO; GO:0021591; P:ventricular system development; ISO:RGD.
DR InterPro; IPR026224; DPCD.
DR PANTHER; PTHR31921; PTHR31921; 1.
DR Pfam; PF14913; DPCD; 1.
DR PRINTS; PR02065; PROTEINDPCD.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..203
FT /note="Protein DPCD"
FT /id="PRO_0000323725"
FT VAR_SEQ 1..90
FT /note="MAVTSWLEILRSAEKTALLQDGKRMVHYLFPDGKEMAEEYDEKTSELLVRKW
FT RVKNALGALGQWQLEVGEPMPSGAGSLGSELIKESNAN -> MPWEPWASGSSKWENQC
FT PQELGAWDPSSSRK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032083"
SQ SEQUENCE 203 AA; 23155 MW; A19503D6DEB11476 CRC64;
MAVTSWLEIL RSAEKTALLQ DGKRMVHYLF PDGKEMAEEY DEKTSELLVR KWRVKNALGA
LGQWQLEVGE PMPSGAGSLG SELIKESNAN PIFMRKDTKT SFQWRIRNLP YPKDVYSVSV
AQKERCVIVR TTNKKYYKKF SIPDLDRHQL PLEDSALSFA HANCTLIISY QKPKEVMAAE
SELQKELKKV KTAHSSDGDC KTQ
