DPCKG_CENSY
ID DPCKG_CENSY Reviewed; 151 AA.
AC A0RW81;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=CENSYa_0966;
OS Cenarchaeum symbiosum (strain A).
OC Archaea; Thaumarchaeota; Cenarchaeales; Cenarchaeaceae; Cenarchaeum.
OX NCBI_TaxID=414004;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A;
RX PubMed=17114289; DOI=10.1073/pnas.0608549103;
RA Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y.,
RA Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F.;
RT "Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum
RT symbiosum.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR EMBL; DP000238; ABK77598.1; -; Genomic_DNA.
DR AlphaFoldDB; A0RW81; -.
DR STRING; 414004.CENSYa_0966; -.
DR EnsemblBacteria; ABK77598; ABK77598; CENSYa_0966.
DR KEGG; csy:CENSYa_0966; -.
DR HOGENOM; CLU_120795_1_0_2; -.
DR OMA; AIYDHKT; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000000758; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Reference proteome; Transferase.
FT CHAIN 1..151
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_0000380044"
SQ SEQUENCE 151 AA; 15839 MW; 18636056E480B97E CRC64;
MGTLILDSMV NKEAVLREAP PGTILVTVGD VTSERISGFG MTPLLQIIDG KTRRAAHEPA
GPPPDVEIIR CENPAGGISP ECIETIRRAL GSSSPLRLVV SGEEDLLVIP ACIYAPDGAV
IMYGQPGRGL VAIHVDAGIR YKAKGLLDSV S