DPCKG_HALWD
ID DPCKG_HALWD Reviewed; 186 AA.
AC Q18KI2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=HQ_1339A;
OS Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloquadratum.
OX NCBI_TaxID=362976;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16790 / HBSQ001;
RX PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA Pfeiffer F., Oesterhelt D.;
RT "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT limits of water activity.";
RL BMC Genomics 7:169-169(2006).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR EMBL; AM180088; CAJ51467.1; -; Genomic_DNA.
DR RefSeq; WP_011570624.1; NC_008212.1.
DR AlphaFoldDB; Q18KI2; -.
DR STRING; 362976.HQ_1339A; -.
DR EnsemblBacteria; CAJ51467; CAJ51467; HQ_1339A.
DR GeneID; 4192259; -.
DR KEGG; hwa:HQ_1339A; -.
DR eggNOG; arCOG04076; Archaea.
DR HOGENOM; CLU_120795_0_0_2; -.
DR OMA; AIYDHKT; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000001975; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
DR PIRSF; PIRSF006533; UCP006533; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Reference proteome; Transferase.
FT CHAIN 1..186
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_0000380049"
SQ SEQUENCE 186 AA; 20117 MW; 97ADFCEAA33215A1 CRC64;
MDRLPLELPS SLRQEFKSPF GPVYTDVTQF LTDAGRPIIA VGDIVTYHLQ TVDYTPAVAV
IDGQTKRESV DETVKAALSK HNKRIDVENQ PGTISIALLE ALQTAVETPE SVMIVVDGEE
DLATLPAVLV ARPGGTVVYG QPDQGMVRIA VTPETKITMS RLLKRMDGDA AAAFDRLGVD
RSGDKK