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DPCKG_HYPBU
ID   DPCKG_HYPBU             Reviewed;         171 AA.
AC   A2BJZ2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE   AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN   OrderedLocusNames=Hbut_0437;
OS   Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC   Hyperthermus.
OX   NCBI_TaxID=415426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5456 / JCM 9403 / PLM1-5;
RX   PubMed=17350933; DOI=10.1155/2007/745987;
RA   Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M.,
RA   She Q., Garrett R.A., Klenk H.-P.;
RT   "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT   fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL   Archaea 2:127-135(2007).
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC       hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC         Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABM80303.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000493; ABM80303.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A2BJZ2; -.
DR   STRING; 415426.Hbut_0437; -.
DR   EnsemblBacteria; ABM80303; ABM80303; Hbut_0437.
DR   KEGG; hbu:Hbut_0437; -.
DR   eggNOG; arCOG04076; Archaea.
DR   HOGENOM; CLU_120795_1_0_2; -.
DR   UniPathway; UPA00241; -.
DR   Proteomes; UP000002593; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR   InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR   PANTHER; PTHR40732; PTHR40732; 1.
DR   Pfam; PF04019; DUF359; 1.
PE   3: Inferred from homology;
KW   Coenzyme A biosynthesis; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..171
FT                   /note="GTP-dependent dephospho-CoA kinase"
FT                   /id="PRO_0000380050"
SQ   SEQUENCE   171 AA;  18896 MW;  6AEE1148C3C60481 CRC64;
     MYHLFHSRLC LPQGLRSLLA QRMPAAKLLP NDSAVAAYAR HRRVVAVGDR VSETLIRHGV
     KPWVMVFDCV EARRDKTCPS IPEGYAILRT RNERSTVEPG AVEVIRKALR QGHTVVRVDG
     EEDLLALPAL LYGDVGSVVL YGLPGKGVVA AAVNREAKLL AMRVLEFFEP C
 
 
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