DPCKG_HYPBU
ID DPCKG_HYPBU Reviewed; 171 AA.
AC A2BJZ2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=Hbut_0437;
OS Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC Hyperthermus.
OX NCBI_TaxID=415426;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5456 / JCM 9403 / PLM1-5;
RX PubMed=17350933; DOI=10.1155/2007/745987;
RA Bruegger K., Chen L., Stark M., Zibat A., Redder P., Ruepp A., Awayez M.,
RA She Q., Garrett R.A., Klenk H.-P.;
RT "The genome of Hyperthermus butylicus: a sulfur-reducing, peptide
RT fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C.";
RL Archaea 2:127-135(2007).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABM80303.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000493; ABM80303.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; A2BJZ2; -.
DR STRING; 415426.Hbut_0437; -.
DR EnsemblBacteria; ABM80303; ABM80303; Hbut_0437.
DR KEGG; hbu:Hbut_0437; -.
DR eggNOG; arCOG04076; Archaea.
DR HOGENOM; CLU_120795_1_0_2; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000002593; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Reference proteome; Transferase.
FT CHAIN 1..171
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_0000380050"
SQ SEQUENCE 171 AA; 18896 MW; 6AEE1148C3C60481 CRC64;
MYHLFHSRLC LPQGLRSLLA QRMPAAKLLP NDSAVAAYAR HRRVVAVGDR VSETLIRHGV
KPWVMVFDCV EARRDKTCPS IPEGYAILRT RNERSTVEPG AVEVIRKALR QGHTVVRVDG
EEDLLALPAL LYGDVGSVVL YGLPGKGVVA AAVNREAKLL AMRVLEFFEP C