ID   ADEC2_CARHZ             Reviewed;         570 AA.
AC   Q3AE81;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Adenine deaminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade2 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=CHY_0699;
OS   Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS   Z-2901).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Carboxydothermus.
OX   NCBI_TaxID=246194;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX   PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA   Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA   Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA   Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT   "Life in hot carbon monoxide: the complete genome sequence of
RT   Carboxydothermus hydrogenoformans Z-2901.";
RL   PLoS Genet. 1:563-574(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000141; ABB15047.1; -; Genomic_DNA.
DR   RefSeq; WP_011343629.1; NC_007503.1.
DR   AlphaFoldDB; Q3AE81; -.
DR   SMR; Q3AE81; -.
DR   STRING; 246194.CHY_0699; -.
DR   EnsemblBacteria; ABB15047; ABB15047; CHY_0699.
DR   KEGG; chy:CHY_0699; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002706; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..570
FT                   /note="Adenine deaminase 2"
FT                   /id="PRO_0000292378"
SQ   SEQUENCE   570 AA;  61600 MW;  47EFFF8C00F1B291 CRC64;
     MKPIKDLVEV ALGKKPADLV LKNAQVFNSF TGEFVTGDVA VVAGYIAGTG EYEGKTTYDL
     QGAYVTPGFI DGHVHIESSM VAPAEFARAL VPAGTLTAVV DPHEIANVSG TAGIRYMLEA
     SSNLPINIYL MLPSCVPATS LETAGAVLTA RELSEFINHP RVLGLGELMD YPGVLNTHEE
     MLKKLAVTEG KLIDGHAPGI SGKELTAYIA AGVNSEHECT TAEEARERLS RGMYLMLREG
     SATKNLLDLL PAVDRYTASR CFFVTDDRHP EDLIKLGSIN HMVKLAVSAG ADLPTVLQMA
     TINAANYFRL YDLGAIAPGY RADILVFEDL QEFKPKYVFK DGKLVAENGK PLFTGYPVDD
     RAVRNTMRLK EINPEKLKIP AKSNRARVIG LIPHQIVTKK LELEVPVEGG YFKTSTEKDI
     AKLAVFERHN YTGNVGVGLI HGLGLKKGAI ASTVAHDSHN LVVAGMSDED IIAAVEELKR
     IGGGLTVVAD GQVLGSLPLP IAGLMSDRTL YEVQEELEKL HRIVRNLGVS ENYDPFMTLA
     FLSLPVIPEL KLTDLGLVDV STFSVVPVSL