ID   DPCKG_METS3             Reviewed;         169 AA.
AC   A5UJM2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE   AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN   OrderedLocusNames=Msm_0195;
OS   Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=420247;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35061 / DSM 861 / OCM 144 / PS;
RX   PubMed=17563350; DOI=10.1073/pnas.0704189104;
RA   Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B.,
RA   Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.;
RT   "Genomic and metabolic adaptations of Methanobrevibacter smithii to the
RT   human gut.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC       hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC         Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR   EMBL; CP000678; ABQ86400.1; -; Genomic_DNA.
DR   RefSeq; WP_011953749.1; NC_009515.1.
DR   AlphaFoldDB; A5UJM2; -.
DR   STRING; 420247.Msm_0195; -.
DR   EnsemblBacteria; ABQ86400; ABQ86400; Msm_0195.
DR   GeneID; 5216300; -.
DR   KEGG; msi:Msm_0195; -.
DR   PATRIC; fig|420247.28.peg.199; -.
DR   eggNOG; arCOG04076; Archaea.
DR   HOGENOM; CLU_120795_1_0_2; -.
DR   OMA; AIYDHKT; -.
DR   BioCyc; MSMI420247:GHWZ-196-MON; -.
DR   UniPathway; UPA00241; -.
DR   Proteomes; UP000001992; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR   InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR   PANTHER; PTHR40732; PTHR40732; 1.
DR   Pfam; PF04019; DUF359; 1.
DR   PIRSF; PIRSF006533; UCP006533; 1.
PE   3: Inferred from homology;
KW   Coenzyme A biosynthesis; Kinase; Transferase.
FT   CHAIN           1..169
FT                   /note="GTP-dependent dephospho-CoA kinase"
FT                   /id="PRO_0000380059"
SQ   SEQUENCE   169 AA;  18888 MW;  9A684B5AD3AD5D0C CRC64;
     MLRLDAELNK DTISKLKKPL GKLYPHFEDA IEEIKSSEFL ISVGDATFNN LTKYELYPDI
     GIIDNLIQRK NHNHEVIKAE NILKAKNPAG TITDDLWETI GQAMKLSGDG NCHVIEVDGE
     EDLAVLPCIL MASDETTILY GQPNEGLVLL KVCDAKDYAQ NLIDTFIKE