DPCKG_METTP
ID DPCKG_METTP Reviewed; 178 AA.
AC A0B8S7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=Mthe_1323;
OS Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS PT) (Methanosaeta thermophila).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=349307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT "Complete sequence of Methanosaeta thermophila PT.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR EMBL; CP000477; ABK15101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0B8S7; -.
DR STRING; 349307.Mthe_1323; -.
DR EnsemblBacteria; ABK15101; ABK15101; Mthe_1323.
DR KEGG; mtp:Mthe_1323; -.
DR HOGENOM; CLU_120795_1_0_2; -.
DR OMA; AIYDHKT; -.
DR BioCyc; MTHE349307:G12X8-1335-MON; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000000674; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
DR PIRSF; PIRSF006533; UCP006533; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Reference proteome; Transferase.
FT CHAIN 1..178
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_0000380062"
SQ SEQUENCE 178 AA; 19834 MW; CF039A8484799A31 CRC64;
MRVLVLPEEL RDELKEPLGV LYRCHGVECV ERMSDHLRAA ERVIAVGDIT TFYLLKASFI
PDLMIVDHKT KRSPVEDSIK RRHLEGSYRV VNVENPAGTL TEELLDAVRE SLNGCTPTEI
IVDGEEDLAA LPAILYAPLG SAVVYGQPSV GSVLVMVTPE KKREIEGILR RMTVKEKV