DPCKG_PYRAB
ID DPCKG_PYRAB Reviewed; 179 AA.
AC Q9UY21; G8ZK48;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=PYRAB16870; ORFNames=PAB1106;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR EMBL; AJ248288; CAB50591.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE71155.1; -; Genomic_DNA.
DR PIR; A75019; A75019.
DR RefSeq; WP_010868805.1; NC_000868.1.
DR AlphaFoldDB; Q9UY21; -.
DR STRING; 272844.PAB1106; -.
DR EnsemblBacteria; CAB50591; CAB50591; PAB1106.
DR GeneID; 1495984; -.
DR KEGG; pab:PAB1106; -.
DR PATRIC; fig|272844.11.peg.1801; -.
DR eggNOG; arCOG04076; Archaea.
DR HOGENOM; CLU_120795_1_0_2; -.
DR OMA; AIYDHKT; -.
DR OrthoDB; 116732at2157; -.
DR PhylomeDB; Q9UY21; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
DR PIRSF; PIRSF006533; UCP006533; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Transferase.
FT CHAIN 1..179
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_0000137613"
SQ SEQUENCE 179 AA; 19929 MW; E5A0E1088B591A32 CRC64;
MKVLFKLPPS LRSELKKPVG ELIEGDIPTP YLKVKDILTN EDPLVTVGDV VTENIMKVGL
NPNLAIYDHK TERREYKPNI RSVEGVLITV KNPPGTITLP LLKAIKKAYS LLSHGKRVHI
VVDGEEDLAT IPAVLYAPIG TTVIYGQPKK GIVLIKVTNE CKRRCAKIMR RMEVVRNGD
