DPCKG_SULIK
ID DPCKG_SULIK Reviewed; 179 AA.
AC C4KIC5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN OrderedLocusNames=M164_1735;
OS Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=426118;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.16.4 / Kamchatka #3;
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
CC -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR EMBL; CP001402; ACR42339.1; -; Genomic_DNA.
DR RefSeq; WP_012736046.1; NC_012726.1.
DR AlphaFoldDB; C4KIC5; -.
DR EnsemblBacteria; ACR42339; ACR42339; M164_1735.
DR GeneID; 7940366; -.
DR KEGG; sid:M164_1735; -.
DR HOGENOM; CLU_120795_1_0_2; -.
DR OMA; AIYDHKT; -.
DR BioCyc; SISL426118:GI01-1788-MON; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000001479; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR PANTHER; PTHR40732; PTHR40732; 1.
DR Pfam; PF04019; DUF359; 1.
DR PIRSF; PIRSF006533; UCP006533; 1.
PE 3: Inferred from homology;
KW Coenzyme A biosynthesis; Kinase; Transferase.
FT CHAIN 1..179
FT /note="GTP-dependent dephospho-CoA kinase"
FT /id="PRO_1000212165"
SQ SEQUENCE 179 AA; 20355 MW; F30109FE9343D2D1 CRC64;
MEIRDNNKVN LCFAFDNLRK ELSRPYGILF TNNKVFLDFV SKSIQQGFKV ITVGDYVSRV
LEENGIIPFL EVIDGKTKRS IPQHRAIVKN KEYRVTNEAG KIQFEIFEII ENILKDRDGG
VVFVNGEEDL LVIPVILSAN NGDIVIYGQP NAGAVVIIVN EMIKWRVRDI LEKAVVEEC