ID   DPCKG_SULIL             Reviewed;         178 AA.
AC   C3MQZ9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=GTP-dependent dephospho-CoA kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            EC=2.7.1.- {ECO:0000255|HAMAP-Rule:MF_00590};
DE   AltName: Full=Dephospho-coenzyme A kinase {ECO:0000255|HAMAP-Rule:MF_00590};
DE            Short=DPCK {ECO:0000255|HAMAP-Rule:MF_00590};
GN   OrderedLocusNames=LS215_1816;
OS   Sulfolobus islandicus (strain L.S.2.15 / Lassen #1).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=429572;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L.S.2.15 / Lassen #1;
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of the 3'-
CC       hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + GTP = CoA + GDP + H(+);
CC         Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00590};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
CC   -!- SIMILARITY: Belongs to the GTP-dependent DPCK family.
CC       {ECO:0000255|HAMAP-Rule:MF_00590}.
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DR   EMBL; CP001399; ACP35812.1; -; Genomic_DNA.
DR   RefSeq; WP_012713909.1; NC_012589.1.
DR   AlphaFoldDB; C3MQZ9; -.
DR   EnsemblBacteria; ACP35812; ACP35812; LS215_1816.
DR   GeneID; 7810853; -.
DR   GeneID; 8761779; -.
DR   KEGG; sis:LS215_1816; -.
DR   HOGENOM; CLU_120795_1_0_2; -.
DR   OMA; AIYDHKT; -.
DR   OrthoDB; 116732at2157; -.
DR   UniPathway; UPA00241; -.
DR   Proteomes; UP000001747; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   HAMAP; MF_00590; Dephospho_CoA_kinase_GTP_dep; 1.
DR   InterPro; IPR007164; GTP-dep_dephospho-CoA_kin.
DR   PANTHER; PTHR40732; PTHR40732; 1.
DR   Pfam; PF04019; DUF359; 1.
DR   PIRSF; PIRSF006533; UCP006533; 1.
PE   3: Inferred from homology;
KW   Coenzyme A biosynthesis; Kinase; Transferase.
FT   CHAIN           1..178
FT                   /note="GTP-dependent dephospho-CoA kinase"
FT                   /id="PRO_1000212166"
SQ   SEQUENCE   178 AA;  20324 MW;  889A00A3C6558CEC CRC64;
     MEIRDNNKVN LCFAFDNLRK ELSRPYGILF TNNKLFLDFV SKSIQQGFKV ITVGDYVSRV
     LEENGIIPFL EVIDGKTKRS IPQRTIVKNK EYRVTNEAGK IRFEIFEIME NILKDRDGGV
     VFVNGEEDLL VIPVTLSADN GDIVIYGQPN AGAVVIIVNE MIRWRVRDIL EKAVVKEC