ID   ADEC2_LATSS             Reviewed;         580 AA.
AC   Q38V07;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Adenine deaminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade2 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC2;
GN   OrderedLocusNames=LCA_1670;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CR936503; CAI55977.1; -; Genomic_DNA.
DR   RefSeq; WP_011375362.1; NC_007576.1.
DR   AlphaFoldDB; Q38V07; -.
DR   SMR; Q38V07; -.
DR   STRING; 314315.LCA_1670; -.
DR   EnsemblBacteria; CAI55977; CAI55977; LCA_1670.
DR   KEGG; lsa:LCA_1670; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..580
FT                   /note="Adenine deaminase 2"
FT                   /id="PRO_0000292385"
SQ   SEQUENCE   580 AA;  61849 MW;  62E5816D90C9E22E CRC64;
     MDKSTLKQLI DQAAGRKPAD TIIKNAKIVD VYNARIIEGT LAIADSRFLG IDAAYTADNV
     INAHGQYVVP GLIDPHIHIE SANVSPAVFG SLVTPHGTTT ILADPHEIVN VAGMRGLEYM
     VASAKNTALD IKYTMPSCVP AANPTLETSG AVITADEIKQ SYDQGLTYGL AEFMNYPGVV
     NADDGVLDEL LVSLNARKMI DGHSPALHGQ GLNAYAAAGV HNDHECTQVD EMLDRISRGM
     YVYLRYGTVS KNMPTLLKGV TPQNARFCCL CGDDLQSVTL RETGHLDESI RVAIQNGIDP
     LTAIQMATIN TAQCTGLSDR GGIAPGLKAD FLLVDDLEHF NVNQTFIDGQ KIAANGAYLL
     PTDDSVAGFD DLLETVHLDN FSADQLKLNL TSDKAHVIGL QSISRTQNLV LPVAHDAEGD
     FHYKPSEDIV KVAVVERHHL TGNVGVGLLS GFGLQNGAIA TSIGHDSHNL VVVGTNDADM
     VVAIDALKAC QGGGVAVQNG QVIATLPFVI GGLMSTEPID SLIAHQKAFN TICHEQLNVT
     AQFDPIMKLG AMPLDVIPNL RITDKGLVDV TKFEIIDINA