ID   ADEC2_RHIL3             Reviewed;         595 AA.
AC   Q1MCF8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Adenine deaminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade2 {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=RL3883;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA   Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA   East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA   Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT   components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AM236080; CAK09373.1; -; Genomic_DNA.
DR   RefSeq; WP_011653318.1; NC_008380.1.
DR   AlphaFoldDB; Q1MCF8; -.
DR   SMR; Q1MCF8; -.
DR   STRING; 216596.RL3883; -.
DR   EnsemblBacteria; CAK09373; CAK09373; RL3883.
DR   KEGG; rle:RL3883; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; IEGHFPG; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese.
FT   CHAIN           1..595
FT                   /note="Adenine deaminase 2"
FT                   /id="PRO_0000292395"
SQ   SEQUENCE   595 AA;  62817 MW;  54D0D1C8F6DC3D5B CRC64;
     MNATARQEPA DLNDPALRAR AVTAARGDAP FDMLITGGRL LDTVTGLIRQ ADIGLVGALI
     SSVHAPASRT DAVEIIDAAG SILTPGLIDT HMHIESSMVT PAEYASAVLP RGVTTIVWDP
     HEFGNVHGLD GVRWAIEAAR SLPLRMILLA PSCVPSAPGL ELAGADFDAS MITEMLHSSA
     VGGVAEVMNM RGVIDGDPRM TDIVNAGLAA GKLVCGHARG LEGADLNAFM ASGITSDHEL
     TSGADLLAKL SAGLTIELRG SHDHLLQEFV EVLSGLGHLP PTVTLCTDDV FPDELQEGGG
     LDDVVRRLVR YGMKPEWAIR AATFNAAQRL KRSDLGLVAT GRRADIVLFE DLTEFRARLV
     ISGGRIVARN GSMQVAVQQI DTAPLVNSVK LPPLTENDFR IPAKGERVRV ATIDRPRFTQ
     WGEAETEVRD GFIVPPAGSA MISVAHRHGK TDGIPRIGFL TGWGEWRGAF CTTVSHDSHN
     LTVFGGNAGD MALAANAVIS AGGGMAVAKD GRIEAMLPLP LSGLVTDASL KDTALAFAGI
     RKAMEKIVTW KPPYLVFKAC FGATLACNVG PHQTDQGIAD VVTGKVLENP VLAVW