ID   ADEC3_RHIME             Reviewed;         595 AA.
AC   Q92YE2;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Adenine deaminase 3 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 3 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 3 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade3 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC3;
GN   OrderedLocusNames=RA0942; ORFNames=SMa1715;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE006469; AAK65600.1; -; Genomic_DNA.
DR   PIR; F95379; F95379.
DR   RefSeq; NP_436188.1; NC_003037.1.
DR   RefSeq; WP_010967905.1; NC_003037.1.
DR   AlphaFoldDB; Q92YE2; -.
DR   SMR; Q92YE2; -.
DR   EnsemblBacteria; AAK65600; AAK65600; SMa1715.
DR   GeneID; 61599696; -.
DR   KEGG; sme:SMa1715; -.
DR   PATRIC; fig|266834.11.peg.971; -.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; MVTACAY; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Plasmid; Reference proteome.
FT   CHAIN           1..595
FT                   /note="Adenine deaminase 3"
FT                   /id="PRO_0000142434"
SQ   SEQUENCE   595 AA;  62982 MW;  768B78A2918375B0 CRC64;
     MLQPWSEIAP RLVDVAMGRK PADLVVRNGR WVNVYSGEIV PGADIAIVGG RFAYVGPDAG
     HTIGEGTKIV DAAGRYLVPG LCDGHMHVES GLVTVTEFAR AVIPHGTTTM FVDPHEIANV
     LGIAGVKLMN DEAQTLPVNI FVQVPSCVPS APGLENAGAT LSAADVREAL AWPNIIGLGE
     MMNFPGVAAN DSKMVAEIAA TRAAGLTVGG HYASPDLGRA FHAYAAGGPA DDHEGTTVED
     AIARVRQGMR SMLRLGSAWF DVAAQVKAIT ERGIDPRNFV LCTDDSHSGT LVSDGHMNRV
     VRHAISQGLK PITAIQMATL NTAQHFGLER DLGSIAPGRR ADLIVTSDLT ALPIEIVFVR
     GRLLAEKGVL VADIPAYDYP ASAKNTVKLG KRLAPTDFDI CAAGSSEVEV RVIGVIENQA
     PTKALQRRLP VECGVVQMDR ASDVCQIALV ERHRATGGVI NAFVSGFGYD THCAMASTVA
     HDSHHMIVVG TNKADMAQAA NRLQEVGGGI VLIAGGRELA LVELPVAGLM SDQRAEIVAE
     KASRLVEAMR ACGCKLNNAY MQHSLLALVV IPELRISDVG LIDVTRFEST EVIVR