ID   ADEC4_RHIME             Reviewed;         600 AA.
AC   Q92YE0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Adenine deaminase 4 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase 4 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase 4 {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade4 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC4;
GN   OrderedLocusNames=RA0944; ORFNames=SMa1718;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE006469; AAK65602.1; -; Genomic_DNA.
DR   PIR; H95379; H95379.
DR   RefSeq; NP_436190.1; NC_003037.1.
DR   RefSeq; WP_010967907.1; NC_003037.1.
DR   AlphaFoldDB; Q92YE0; -.
DR   SMR; Q92YE0; -.
DR   EnsemblBacteria; AAK65602; AAK65602; SMa1718.
DR   GeneID; 61599698; -.
DR   KEGG; sme:SMa1718; -.
DR   PATRIC; fig|266834.11.peg.973; -.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; GHIHVEC; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Plasmid; Reference proteome.
FT   CHAIN           1..600
FT                   /note="Adenine deaminase 4"
FT                   /id="PRO_0000142435"
SQ   SEQUENCE   600 AA;  65053 MW;  3F229708FAEC38C5 CRC64;
     MSDVREFIRA ASGGESKATV AVCGGRLVNV VSEEIYQADV AIYRDRIIAV GDISEYIGPQ
     TEIIDAADRY LTPGMIDGHL HVECSKLSLT SFAKAVLPLG TTSIVSGLDQ IIVVGGPDAA
     REFLDEVRQT PLKVFWGAPC KTPYTMPRST VGHYFSPKDH RDTHHWPECV GIWETVREFI
     QEEDEDVLQA IEIGQANRLP VLGCCPMTRG ARLNGYMQSG VRADHESYTP EEMLEKLRAG
     MHVVVRESSI SHFLSDNLRI VTEMGVKALR RISFCTDDVV ASDILSRGHL DNMVRMAMAM
     GISPMAAIQM ATINGAEALR IDHKVGSISP GRTADILIVN DLRDFRIEAV VANGTVAARD
     GRMVVKLVPP QRSAGLLRSV KTTPVTAADI AVPFTGTTPF AEVLAIAVTP EKVFVRTRRD
     VRLPVVDGKI LADASQNVQY VTVVERYGKT LNRPVAFVSG FNLKSGAIAS STAPDDNNII
     CIGADPQDMA IAINHLVANN GGQVVVDKGE VVEFLHLPIG GIVSDIDPAE MAAFELRLDE
     AARRLGCDLP WPFMYMFVLQ ITAIPDYAMT DLGVVDCVNL RIISPLAPDG PAKANTLAAE