ID   ADEC_ALKHC              Reviewed;         585 AA.
AC   Q9KF46;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=BH0640;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; BA000004; BAB04359.1; -; Genomic_DNA.
DR   PIR; H83729; H83729.
DR   RefSeq; WP_010896816.1; NC_002570.2.
DR   AlphaFoldDB; Q9KF46; -.
DR   SMR; Q9KF46; -.
DR   STRING; 272558.10173254; -.
DR   EnsemblBacteria; BAB04359; BAB04359; BAB04359.
DR   KEGG; bha:BH0640; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..585
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142400"
SQ   SEQUENCE   585 AA;  63055 MW;  A6041ED63699655D CRC64;
     MTDRLERKLA IAANQDKADL LIKNGQIVDV FQLETFEGDV VIADGEIVAI SDPGTYEAHE
     EVDAKGAFIA PAFIDGHVHI ESSMVAPEQF AKVVVPHGVT TVIADPHEIA NVAGVQGVEY
     MLDASEGIPL DVKMMVPSCV PATPFEHSGA RLTAEEVAEL FRDPRIFGLG EVMDYPAVLT
     RDQEMMAKLK AAHSEGRIVD GHGAGLDSVA LNAYTAAGIG NDHEAVTPEE AKARLQRGMY
     LLIREGTAAK DFDALMKAIT PMNSRRALFV TDDKHLDELV EEGSIDHHVR KAIQIGVNPL
     QAIQMASLNA AECFKLAKKG AIAPGFTADL LFIEDLQSLA ITHVFKNGTC VAKNGKLIVP
     IRETVQPPQR LLESVNMKLV TKEQLELSLQ SDEEAHLIQI QPGSIVTKHI REKVAVKDGV
     FIPSVARDQL KLVVAERHHK RGTVGVGIVK GFGLTKGAIA TTVAHDSHNI VAVGTNDEDL
     LAAIKELENI QGGMTIVKDG KVLVSLPLTI GGLMSDQSYD VVCEQIKSVD AAIGALGFVG
     DFNPFLTLSF LALPVIPEIK LTDQGLFDVT SFSFIDQQVY AEETN