ID   ADEC_BACLD              Reviewed;         573 AA.
AC   Q65K51;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=BLi01667, BL01613;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE017333; AAU40563.1; -; Genomic_DNA.
DR   EMBL; CP000002; AAU23205.1; -; Genomic_DNA.
DR   RefSeq; WP_011197948.1; NC_006322.1.
DR   AlphaFoldDB; Q65K51; -.
DR   SMR; Q65K51; -.
DR   STRING; 279010.BL01613; -.
DR   PRIDE; Q65K51; -.
DR   EnsemblBacteria; AAU23205; AAU23205; BL01613.
DR   KEGG; bld:BLi01667; -.
DR   KEGG; bli:BL01613; -.
DR   PATRIC; fig|279010.13.peg.1664; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   BioCyc; BLIC279010:BLI_RS08250-MON; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..573
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142401"
SQ   SEQUENCE   573 AA;  62082 MW;  7A47B4C7910361B1 CRC64;
     MDKEMFIRRL GAASHRKKAE TVIKNGKIMD VFNQEWLETD IAITDGAIVG LGEYEGGNII
     DAEGQMIVPG FIDGHVHIES SMVTPPEFAK AVIPHGVTTV VTDPHEIANV SGVKGLEFML
     EQAEMTRLNI YFMLPSCVPA APFEKSGAIL NAADLHPFYS REEVLGLAEV MDYVAVEAGE
     PDMVQKLIDA DKAGKRIDGH LAGLSAGFVN VYRAAGVLTD HEVTTPEEAL ERVRRGMYVM
     LREGSAAKNT RHVLPAVNEK NVRRFFFCTD DKHLDELVDE GSINYQVKLA IQEGLDPFLA
     YQMGSLNAAE CFGLKTKGAV APGYDADLLF ISDFENVSIT KTMINGVIWS GTEQSQSTGG
     KAASGLLQSV HLSDLHENDL QIPIVQENEI RVIDIIPNQL ETKLSLAKPK SGAFFQPDLE
     SDLLKIAVVE RHRGVKEIGL GVVRGFGLKE GAIATTISHD SHNLIAVGTN DQDILKAIER
     LGEIGGGLTI AKGGKELQSV ALPIAGLLSD KPLETVNESL KSLHAAITET GFSGAFNPFL
     TLSFLALPVI PDIKMTTEGL FDVKAFRHIP VQP