ID   ADEC_BACP2              Reviewed;         576 AA.
AC   A8FCR4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=BPUM_1348;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000813; ABV62031.1; -; Genomic_DNA.
DR   RefSeq; WP_012009817.1; NC_009848.4.
DR   AlphaFoldDB; A8FCR4; -.
DR   SMR; A8FCR4; -.
DR   STRING; 315750.BPUM_1348; -.
DR   EnsemblBacteria; ABV62031; ABV62031; BPUM_1348.
DR   KEGG; bpu:BPUM_1348; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..576
FT                   /note="Adenine deaminase"
FT                   /id="PRO_1000068608"
SQ   SEQUENCE   576 AA;  62999 MW;  97E4AA8F69AC280C CRC64;
     MDKELFRHQI EVAAKRKKAA LVIKHAKVMD VFNQEWIDAD VAVENGQIVG IGEYEGEQEL
     DAVGQMLVPG FIDGHVHIES SMVTPAEFSK AVVPHGVTTV VTDPHEIANV SGITGIRFML
     EEAKKAALHI YFMLPSCVPA VSFERSGATL KAKDLKPLYQ EKEVLGLAEV MDYVGVEQAE
     EDMLQKLLDA QHENKLIDGH LAGLTDRLIN VYRTASVQTD HEVTTAQEAL ERVKRGMYVM
     LREGSVAKNV KNVLPAVNEK NARRFFFCTD DKHLDDLMAQ GSIDEQVRMS IKEGLDPFLA
     YQMGSLNAAE CFGLKTKGAI APGYDADFML VSDFHHVDIT SVFIAGELVA QNGEYKPSVE
     KIAPSPALLQ SVHAIDVQEE DIALPITGDQ HMNVIRIIPN QLETKLEQVS PSEMNGQFTS
     DTGRDVLKMV LVERHQGLSE MGVGIVSGFG IKQGAIATTV AHDSHNLIAV GTNDADIIKA
     IEALKEAGGG LTVVKEGQSL HTLPLPISGL LSDQPAHLVN ESLHSLHEAL KETGFSLDFN
     PFLTLSFLAL PVIPDVKMTT KGLFDVRNFQ HLPIQS