ID   ADEC_BRASB              Reviewed;         600 AA.
AC   A5EGE2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=BBta_3118;
OS   Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=288000;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTAi1 / ATCC BAA-1182;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000494; ABQ35236.1; -; Genomic_DNA.
DR   RefSeq; WP_012043254.1; NC_009485.1.
DR   AlphaFoldDB; A5EGE2; -.
DR   SMR; A5EGE2; -.
DR   STRING; 288000.BBta_3118; -.
DR   EnsemblBacteria; ABQ35236; ABQ35236; BBta_3118.
DR   KEGG; bbt:BBta_3118; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_5; -.
DR   OMA; MVTACAY; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000000246; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese.
FT   CHAIN           1..600
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000296716"
SQ   SEQUENCE   600 AA;  63618 MW;  0A18C2BD8938C257 CRC64;
     MTKLTRFSVA PLHAMTRRLA DVASGRVAPE FVITGARVLS TYSERILPNR ELWITGGRVA
     AVKPAGAHKA LGGGFAIYDA ADGIIAPGLV DPHIHIESSM VTACAYAEAA LLNGTTTIFC
     DSHEIGNVMD VAGVEAMLED ARQAPLSIFL TVPSTVPATS AALETAGGDL TPDKIADLFD
     RWPEAVALGE KMDFVPVCMG DERSHAILAA ALQRGRPVSG HVYGREFVAA YAASGVTDTH
     EAIDRDIADD LLDAGVWIFL RGGPPTTPWH SLPQAIRTIT ELGASHKRTA VCTDDRDADD
     LMLFGLDWVV REAVKAGMSP EQAWSMGSLH GATRFAMDGE IGGLGGGRRA DLVLLDDGLK
     PQSTWYGGEL VVENGKITPR LDQALSQRYQ YPKAAYATVK LPAQVKLTPE LPTKACTVNA
     IKTALPGITL IHDKVAIAPA SDWPTLFARH GLCFVAVIER HGKSAGNVAH GLLKDFGLTR
     GAVASSVGHD SHNIIVAGTN EADMQVAVAA IGSHQGGVCV VADGKVRAMV PLPIAGLLSD
     KRITEVAEEV KLLKTEWAAA GCTIPYMGFN LIPLSVIPEI RITDKGLVLV PQMELTPLFE