ID   DPM1L_HALVD             Reviewed;         228 AA.
AC   D4GZ42;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Dolichyl-phosphate hexose transferase HVO_1613;
DE            EC=2.4.1.-;
GN   OrderedLocusNames=HVO_1613; ORFNames=C498_03430;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=DS2 / DS70;
RX   PubMed=20802039; DOI=10.1128/jb.00705-10;
RA   Kaminski L., Abu-Qarn M., Guan Z., Naparstek S., Ventura V.V., Raetz C.R.,
RA   Hitchen P.G., Dell A., Eichler J.;
RT   "AglJ adds the first sugar of the N-linked pentasaccharide decorating the
RT   Haloferax volcanii S-layer glycoprotein.";
RL   J. Bacteriol. 192:5572-5579(2010).
CC   -!- FUNCTION: Glycosyltransferase that adds a monosaccharide to dolichol
CC       phosphate, thereby being responsible for generating one of the three
CC       monosaccharide-modified dolichol phosphates. The subunit onto which
CC       additional sugars are added is not known.
CC       {ECO:0000269|PubMed:20802039}.
CC   -!- DISRUPTION PHENOTYPE: Cells do not generate the small monosaccharide-
CC       charged dolichol phosphate species. {ECO:0000269|PubMed:20802039}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR   EMBL; CP001956; ADE02947.1; -; Genomic_DNA.
DR   EMBL; AOHU01000029; ELY35628.1; -; Genomic_DNA.
DR   RefSeq; WP_004041505.1; NZ_AOHU01000029.1.
DR   AlphaFoldDB; D4GZ42; -.
DR   SMR; D4GZ42; -.
DR   STRING; 309800.C498_03430; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   EnsemblBacteria; ADE02947; ADE02947; HVO_1613.
DR   EnsemblBacteria; ELY35628; ELY35628; C498_03430.
DR   GeneID; 8923970; -.
DR   KEGG; hvo:HVO_1613; -.
DR   PATRIC; fig|309800.29.peg.665; -.
DR   eggNOG; arCOG00895; Archaea.
DR   HOGENOM; CLU_033536_7_3_2; -.
DR   OMA; MGTYNEE; -.
DR   OrthoDB; 63636at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   Proteomes; UP000011532; Unassembled WGS sequence.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..228
FT                   /note="Dolichyl-phosphate hexose transferase HVO_1613"
FT                   /id="PRO_0000428779"
SQ   SEQUENCE   228 AA;  25091 MW;  CF5FE3D548E2F7BF CRC64;
     MTEYTFDDLA VVMGTYNEEQ AIGSVLADID RITDGRAEVV CVDGSDDRTP EIARKMGARV
     IEQEPQGYGV AVEAAVLAPD RPVVVTTDCD DTYPMEYLPK FLDLINDGYD VVSGDRITKG
     AETMPRLNRA GNIAFARLAS FLMGATVHDT TTGMRAYRRE LLHDIEWTEN TGLSAELLIR
     PAMRGYNIAE VPIPYRERAG ETKLDPFAGG AAIGKSIVKV CLEERLRL