DPM1_DROME
ID DPM1_DROME Reviewed; 241 AA.
AC Q9VIU7;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Dolichol-phosphate mannosyltransferase subunit 1 {ECO:0000312|FlyBase:FBgn0032799};
DE Short=DPM synthase;
DE Short=Dolichol-phosphate mannose synthase;
DE EC=2.4.1.83;
DE AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase;
DE AltName: Full=Mannose-P-dolichol synthase;
DE Short=MPD synthase;
GN Name=Dpm1 {ECO:0000312|FlyBase:FBgn0032799};
GN ORFNames=CG10166 {ECO:0000312|FlyBase:FBgn0032799};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Transfers mannose from GDP-mannose to dolichol monophosphate
CC to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl
CC donor in pathways leading to N-glycosylation, glycosyl
CC phosphatidylinositol membrane anchoring, and O-mannosylation of
CC proteins. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta-
CC D-mannosyl phosphate + GDP; Xref=Rhea:RHEA:21184, Rhea:RHEA-
CC COMP:9517, Rhea:RHEA-COMP:9527, ChEBI:CHEBI:57527, ChEBI:CHEBI:57683,
CC ChEBI:CHEBI:58189, ChEBI:CHEBI:58211; EC=2.4.1.83;
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF53817.1; -; Genomic_DNA.
DR RefSeq; NP_609980.1; NM_136136.3.
DR AlphaFoldDB; Q9VIU7; -.
DR SMR; Q9VIU7; -.
DR DIP; DIP-17174N; -.
DR STRING; 7227.FBpp0080817; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR PaxDb; Q9VIU7; -.
DR PRIDE; Q9VIU7; -.
DR DNASU; 35240; -.
DR EnsemblMetazoa; FBtr0081279; FBpp0080817; FBgn0032799.
DR GeneID; 35240; -.
DR KEGG; dme:Dmel_CG10166; -.
DR UCSC; CG10166-RA; d. melanogaster.
DR FlyBase; FBgn0032799; Dpm1.
DR VEuPathDB; VectorBase:FBgn0032799; -.
DR eggNOG; KOG2978; Eukaryota.
DR GeneTree; ENSGT00940000153481; -.
DR HOGENOM; CLU_033536_13_3_1; -.
DR InParanoid; Q9VIU7; -.
DR OMA; TAYIHGF; -.
DR OrthoDB; 1445102at2759; -.
DR PhylomeDB; Q9VIU7; -.
DR Reactome; R-DME-162699; Synthesis of dolichyl-phosphate mannose.
DR UniPathway; UPA00378; -.
DR BioGRID-ORCS; 35240; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG10166; fly.
DR GenomeRNAi; 35240; -.
DR PRO; PR:Q9VIU7; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032799; Expressed in spermathecum and 25 other tissues.
DR ExpressionAtlas; Q9VIU7; baseline and differential.
DR Genevisible; Q9VIU7; DM.
DR GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; ISS:FlyBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; ISS:FlyBase.
DR GO; GO:0019348; P:dolichol metabolic process; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; ISS:FlyBase.
DR GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
DR CDD; cd06442; DPM1_like; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR039528; DPM1-like.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43398; PTHR43398; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..241
FT /note="Dolichol-phosphate mannosyltransferase subunit 1"
FT /id="PRO_0000059172"
SQ SEQUENCE 241 AA; 27002 MW; 45ECC64EF96B0C38 CRC64;
MPTNGHKYSI LMPTYNEKDN LPIIIWLIVK YMKASGLEYE VIVIDDGSPD GTLDVAKDLQ
KIYGEDKIVL RPRGSKLGLG TAYIHGIKHA TGDFIVIIDA DLSHHPKFIP EFIKLQQEGN
YDIVSGTRYA GNGGVFGWDF KRKLISRGAN FLSQVLLRPN ASDLTGSFRL YKKDVLEKCI
ASCVSKGYVF QMEMLVRARQ HGYTIAEVPI TFVDRIYGTS KLGGTEIIQF AKNLLYLFAT
T
