DPM2_DICDI
ID DPM2_DICDI Reviewed; 79 AA.
AC Q556K9; Q86K00;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Dolichol phosphate-mannose biosynthesis regulatory protein;
DE AltName: Full=Dolichol-phosphate mannose synthase subunit 2;
DE Short=DPM synthase subunit 2;
GN Name=dpm2-1; ORFNames=DDB_G0272588;
GN and
GN Name=dpm2-2; ORFNames=DDB_G0273981;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose.
CC Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase
CC complex; essential for the ER localization and stable expression of
CC dpm1 (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBUNIT: Component of the dolichol-phosphate mannose (DPM) synthase
CC complex composed of dpm1, dpm2 and dpm3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DPM2 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70424.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70931.1; -; Genomic_DNA.
DR RefSeq; XP_644349.1; XM_639257.1.
DR RefSeq; XP_645065.1; XM_639973.1.
DR AlphaFoldDB; Q556K9; -.
DR STRING; 44689.DDB0233349; -.
DR PaxDb; Q556K9; -.
DR EnsemblProtists; EAL70424; EAL70424; DDB_G0273981.
DR EnsemblProtists; EAL70931; EAL70931; DDB_G0272588.
DR GeneID; 8618740; -.
DR GeneID; 8619236; -.
DR KEGG; ddi:DDB_G0272588; -.
DR KEGG; ddi:DDB_G0273981; -.
DR dictyBase; DDB_G0272588; dpm2-1.
DR dictyBase; DDB_G0273981; dpm2-2.
DR eggNOG; KOG3488; Eukaryota.
DR HOGENOM; CLU_150144_2_0_1; -.
DR InParanoid; Q556K9; -.
DR OMA; WTLFMPF; -.
DR PhylomeDB; Q556K9; -.
DR Reactome; R-DDI-162699; Synthesis of dolichyl-phosphate mannose.
DR Reactome; R-DDI-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00378; -.
DR PRO; PR:Q556K9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR GO; GO:0019348; P:dolichol metabolic process; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR009914; DPM2.
DR PANTHER; PTHR15039; PTHR15039; 1.
DR Pfam; PF07297; DPM2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..79
FT /note="Dolichol phosphate-mannose biosynthesis regulatory
FT protein"
FT /id="PRO_0000347180"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 79 AA; 9076 MW; 8CC1CA4DEB8DCEF8 CRC64;
MGASDKFIGF VMVLFRIFVF GYYTTWVIIT PFIVSDHWIQ QYFLPREYGI IIPLVLLVVG
ITAIGTFLGL VMIKSKKNK
